CAJ | 학술논문

目的研究乳腺癌中IMP3的表达及其与临床病理特征之间的关系.方法利用组织芯片技术和免疫组织化学EliVision两步法检测214例乳腺癌标本中IMP3的表达.结果 214例乳腺浸润性导管癌中,IMP3阳性表达31例(14.49%).乳腺癌IMP3的阳性表达与乳腺癌的组织学级别(P=0.005)、Ki-67增殖指数(P=0.033)及三阴性表型(P<0.001)密切相关.IMP3的表达与病人年龄、肿瘤最大直径、淋巴结转移数量、pTNM分期和p53表达状况均无关(P>0.05).结论 IMP3表达与乳腺癌组织级别高、Ki-67增殖指数高以及在三阴性亚组表达高相关,预示IMP3与乳腺癌的进展和恶性度相关,并可能作为三阴性乳腺癌的一个辅助诊断指标.
목적 연구유선암중IMP3적표체급기여림상병리특정지간적관계.방법 이용조직심편기술화면역조직화학EliVision량보법검측214례유선암표본중IMP3적표체.결과 214례유선침윤성도관암중,IMP3양성표체31례(14.49%).유선암IMP3적양성표체여유선암적조직학급별(P=0.005)、Ki-67증식지수(P=0.033)급삼음성표형(P<0.001)밀절상관.IMP3적표체여병인년령、종류최대직경、림파결전이수량、pTNM분기화p53표체상황균무관(P>0.05).결론 IMP3표체여유선암조직급별고、Ki-67증식지수고이급재삼음성아조표체고상관,예시IMP3여유선암적진전화악성도상관,병가능작위삼음성유선암적일개보조진단지표.
Purpose To investigate the expression of IMP3 and its relationship with clinicopathological characteristics in breast cancer.Methods By the tissue microarray technique and immunohistochemical EliVision two-step method, expression of IMP3 was detected in 214 cases of breast carcinoma.Results Of the 214 breast cancer cases,IMP3 expression was seen in 31(14.49%). IMP3 expression in the tumor cells was positively correlated with histological grade (P=0.005), proliferative index labeled by Ki-67 (P=0.033) and triple negative phenotype (P<0.001). There were no associations between IMP3 expression and age, tumor size, lymph node metastases, pTNM stage or p53 expression (P>0.05).Conclusions Expression of IMP3 is correlated with higher histologic grade, higher proliferative activity and triple negative breast carcinoma.Our findings indicate that IMP3 plays an important role in breast cancer progression, and IMP3 could be an adjuvant diagnostic marker in triple negative breast carcinoma.