中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2012年
9期
823-825
,共3页
急性心肌梗死%老年%焦虑%抑郁%炎症标志物%帕罗西汀
急性心肌梗死%老年%焦慮%抑鬱%炎癥標誌物%帕囉西汀
급성심기경사%노년%초필%억욱%염증표지물%파라서정
Acute myocardial infarction%Elderly%Anxiety%Depression%Inflammatory markers%Paroxetine
目的 探讨帕罗西汀干预老年急性心肌梗死患者焦虑抑郁情绪及对血清炎症标志物水平的影响.方法 据医院情绪抑郁及焦虑量表评分,入选老年急性心肌梗死合并焦虑和/或抑郁患者136例.根据评分分为焦虑患者(n=54)、抑郁患者(n=39)、焦虑抑郁共病患者(n=43).3类患者在评估后按单双号随机分为帕罗西汀组:在常规治疗基础上,给予帕罗西汀10～20mg/d口服；常规组:依据治疗指南进行常规治疗；28 d后再次据医院情绪抑郁及焦虑量表进行评分.所有入选患者于入选次日晨起及治疗第29天抽取空腹肘静脉血检测高敏C反应蛋白(Hs-CRP),髓过氧化物酶(MPO)及肌钙蛋白Ⅰ(cTnI).结果 1.帕罗西汀组中焦虑患者HADa、抑郁患者HADd、焦虑抑郁共患者HADa及HADd计分治疗后与治疗前比较差异具有统计学意义(P＜0.01)；常规组治疗前后HADS评分差异无显著性；帕罗西汀组中焦虑患者HADa、抑郁患者HADd、焦虑抑郁共患者HADa和HADd计分[分别为(10.52±2.74)分,(10.83±3.25)分,(9.49±2.57)分,(9.99±2.38)分],低于对照组(P＜0.05)；2.焦虑患者帕罗西汀治疗后血清Hs-CRP、cTnI、MPO水平低于常规组(P＜0.05；抑郁患者帕罗西汀治疗后血清Hs-CRP、cTnI、MPO水平低于常规组(P＜0.05)；焦虑抑郁共患者帕罗西汀治疗后血清Hs-CRP、cTnI、MPO水平低于常规组(P＜0.05).结论 帕罗西汀对老年AMI患者焦虑抑郁情绪有显著疗效,显著降低血清炎症标志物水平.
目的 探討帕囉西汀榦預老年急性心肌梗死患者焦慮抑鬱情緒及對血清炎癥標誌物水平的影響.方法 據醫院情緒抑鬱及焦慮量錶評分,入選老年急性心肌梗死閤併焦慮和/或抑鬱患者136例.根據評分分為焦慮患者(n=54)、抑鬱患者(n=39)、焦慮抑鬱共病患者(n=43).3類患者在評估後按單雙號隨機分為帕囉西汀組:在常規治療基礎上,給予帕囉西汀10～20mg/d口服；常規組:依據治療指南進行常規治療；28 d後再次據醫院情緒抑鬱及焦慮量錶進行評分.所有入選患者于入選次日晨起及治療第29天抽取空腹肘靜脈血檢測高敏C反應蛋白(Hs-CRP),髓過氧化物酶(MPO)及肌鈣蛋白Ⅰ(cTnI).結果 1.帕囉西汀組中焦慮患者HADa、抑鬱患者HADd、焦慮抑鬱共患者HADa及HADd計分治療後與治療前比較差異具有統計學意義(P＜0.01)；常規組治療前後HADS評分差異無顯著性；帕囉西汀組中焦慮患者HADa、抑鬱患者HADd、焦慮抑鬱共患者HADa和HADd計分[分彆為(10.52±2.74)分,(10.83±3.25)分,(9.49±2.57)分,(9.99±2.38)分],低于對照組(P＜0.05)；2.焦慮患者帕囉西汀治療後血清Hs-CRP、cTnI、MPO水平低于常規組(P＜0.05；抑鬱患者帕囉西汀治療後血清Hs-CRP、cTnI、MPO水平低于常規組(P＜0.05)；焦慮抑鬱共患者帕囉西汀治療後血清Hs-CRP、cTnI、MPO水平低于常規組(P＜0.05).結論 帕囉西汀對老年AMI患者焦慮抑鬱情緒有顯著療效,顯著降低血清炎癥標誌物水平.
목적 탐토파라서정간예노년급성심기경사환자초필억욱정서급대혈청염증표지물수평적영향.방법 거의원정서억욱급초필량표평분,입선노년급성심기경사합병초필화/혹억욱환자136례.근거평분분위초필환자(n=54)、억욱환자(n=39)、초필억욱공병환자(n=43).3류환자재평고후안단쌍호수궤분위파라서정조:재상규치료기출상,급여파라서정10～20mg/d구복；상규조:의거치료지남진행상규치료；28 d후재차거의원정서억욱급초필량표진행평분.소유입선환자우입선차일신기급치료제29천추취공복주정맥혈검측고민C반응단백(Hs-CRP),수과양화물매(MPO)급기개단백Ⅰ(cTnI).결과 1.파라서정조중초필환자HADa、억욱환자HADd、초필억욱공환자HADa급HADd계분치료후여치료전비교차이구유통계학의의(P＜0.01)；상규조치료전후HADS평분차이무현저성；파라서정조중초필환자HADa、억욱환자HADd、초필억욱공환자HADa화HADd계분[분별위(10.52±2.74)분,(10.83±3.25)분,(9.49±2.57)분,(9.99±2.38)분],저우대조조(P＜0.05)；2.초필환자파라서정치료후혈청Hs-CRP、cTnI、MPO수평저우상규조(P＜0.05；억욱환자파라서정치료후혈청Hs-CRP、cTnI、MPO수평저우상규조(P＜0.05)；초필억욱공환자파라서정치료후혈청Hs-CRP、cTnI、MPO수평저우상규조(P＜0.05).결론 파라서정대노년AMI환자초필억욱정서유현저료효,현저강저혈청염증표지물수평.
Objective To investigate the therapeutic efficacy of paroxetine and influence on inflammatory markers in elderly acute myocardial infarction (AMI) patients with anxiety and depression.Methods 136 patients with AMI graded by " the hospital depression and anxiety" score were divided into three class:(1)patients with anxiety ( n =54) ; (2)Patients with depression ( n =39) ; (3)Patients with anxiety and depression ( n =43 ).136 patients were randomly divided into paroxetine group (paroxetine 10-20 mg/d)and conventional group (conventional drugs based on guidelines).After 28 days treatment,HAD scores,serum level of inflammatory markers (Hs-CRP,MPO,and cTnI ) were compared between two groups.Results (1)HAD scores (HADa and HADd)of paroxetine group were decreased significantly after 28 days treatment (P ＜ 0.01 ) ;while there were no remarkable improvements in conventional group.With paroxetine treatment HAD scores of anxiety,depression,anxiety and depression( 10.52 ± 2.74,10.83 ±3.25,9.49 ± 2.57,9.99 ± 2.38) were much lower than those of conventional group(P ＜ 0.05 ).(2)Serum Hs-CRP,MPO and cTnI of paroxetine group in patients with anxiety were much lower than those of conventional group (P ＜ 0.05 ).Serum Hs-CRP,MPO and cTnI of paroxetine group in patients with depression were much lower than those of conventional group (P ＜ 0.05 ).Serum Hs-CRP,MPO and cTnI of paroxetine group in patients with anxiety and depression were much lower than those of Conventional group (P＜ 0.05 ).Conclusion Paroxetine has remarkable treatment effect in elderly AMI patients with anxiety and depression,and paroxetine call significantly decreased serum levels of inflammatory markers.
