CAJ | 학술논문

目的探讨定期尿激酶封管对血液透析(HD)患者带涤纶环中心静脉留置导管(CVC)功能不良的作用.方法对带涤纶环CVC行HD 132例患者进行前瞻性随机对照研究,不使用尿激酶封管(非尿激酶组)52例,定期使用尿激酶(尿激酶组)80例,分析尿激酶对患者导管功能不良、血流量、透析充分性、贫血及血浆白蛋白的影响.根据置管后3个月内是否出现导管功能不良,计算出3个月内功能不良发生率.记录患者一般临床指标、血流量,计算尿素清除指数( Kt/V)等.结果尿激酶组导管功能不良发生率显著减低(26.3％)显著低于非尿激酶组(32.7％)(x2=32.727,P＜0.01),血流量、Kt/V、血红蛋白及血浆白蛋白水平显著高于非尿激酶组(P＜0.01).结论定期使用尿激酶可减少患者导管功能不良、提高血流量、提高患者透析充分性、使患者贫血减轻、白蛋白升高.
목적 탐토정기뇨격매봉관대혈액투석(HD)환자대조륜배중심정맥류치도관(CVC)공능불량적작용.방법 대대조륜배CVC행HD 132례환자진행전첨성수궤대조연구,불사용뇨격매봉관(비뇨격매조)52례,정기사용뇨격매(뇨격매조)80례,분석뇨격매대환자도관공능불량、혈류량、투석충분성、빈혈급혈장백단백적영향.근거치관후3개월내시부출현도관공능불량,계산출3개월내공능불량발생솔.기록환자일반림상지표、혈류량,계산뇨소청제지수( Kt/V)등.결과 뇨격매조도관공능불량발생솔현저감저(26.3％)현저저우비뇨격매조(32.7％)(x2=32.727,P＜0.01),혈류량、Kt/V、혈홍단백급혈장백단백수평현저고우비뇨격매조(P＜0.01).결론 정기사용뇨격매가감소환자도관공능불량、제고혈류량、제고환자투석충분성、사환자빈혈감경、백단백승고.
Objective To explore the effect of sealing tube with regular urokinase for the malfunction of central venous catheter(CVC) in patients with hemodialysis (HD).Methods This was a prospective randomized controlled study,132 HD patients with cuff CVC were studied.In the early stage,52 H D patients without 80 patients with regular catheter-locking solution of urokinase.To analyze effect of cuff CVC malfunction,blood flow(BF),dialysis adequacy,anemia and serum albumin (ALB) with regular catheter-locking solution of urokinase.The incidence of catheter malfunction was calculated based on the catheter dysfunction in the first 3 months.Clinical index was measured,recorded BF and calculated urea clearance rate (Kt/V).Results HD patients catheter-locking solution with regular urokinase could reduce the incidence of dialysis catheter malfunction ( 26.3％ vs 32.7％,x2 =32.727,P ＜0.01 ),increase the BF,Kt/V,levels of hemoglobin(HGB) and ALB(P＜0.05 or P ＜0.01).Conclusion Regular catheter-locking solution with urokinase is effective in reducing HD patients incidence of dialysis CVC malfunction,increasing patients BF,dialysis adequacy and the level of ALB,improving anemia.