CAJ | 학술논문

目的探讨体外受精获得全部非优质胚胎周期的移植策略.方法回顾性分析浙江大学医学院附属邵逸夫医院1998年12月至2010年6月全部胚胎为非优质胚胎的促排周期资料共621个周期,其中新鲜胚胎移植574个周期、冻融胚胎移植作为体外受精后首次胚胎移植47个周期,应用多因素Logistic回归方法分析临床相关因素与临床妊娠率之间的关系.结果冻融胚胎移植作为体外受精后首次胚胎移植组的临床妊娠率显著高于新鲜胚胎移植组[38.3%(18/47)比22.1%(127/574),P＜0.05];年龄和移植时机与临床妊娠率密切相关,年龄因素校正后仍显示冻融胚胎移植作为体外受精后首次胚胎移植的临床妊娠率高于新鲜胚胎移植组(OR:2.107,95%CI:1.128～3.939,P＜0.05).结论冻融胚胎移植作为体外受精后获得全部非优质胚胎周期的首次胚胎移植,可以获得较新鲜胚胎移植更高的临床妊娠率.
목적 탐토체외수정획득전부비우질배태주기적이식책략.방법 회고성분석절강대학의학원부속소일부의원1998년12월지2010년6월전부배태위비우질배태적촉배주기자료공621개주기,기중신선배태이식574개주기、동융배태이식작위체외수정후수차배태이식47개주기,응용다인소Logistic회귀방법분석림상상관인소여림상임신솔지간적관계.결과 동융배태이식작위체외수정후수차배태이식조적림상임신솔현저고우신선배태이식조[38.3%(18/47)비22.1%(127/574),P＜0.05];년령화이식시궤여림상임신솔밀절상관,년령인소교정후잉현시동융배태이식작위체외수정후수차배태이식적림상임신솔고우신선배태이식조(OR:2.107,95%CI:1.128～3.939,P＜0.05).결론 동융배태이식작위체외수정후획득전부비우질배태주기적수차배태이식,가이획득교신선배태이식경고적림상임신솔.
Objective To investigate the transfer strategy of low-quality embryo in in vitro fertilization and embryo transfer (IVF-ET) cycle. Methods A retrospective analysis was performed for the clinical data of 621 IVF-ET cycles under controlled ovarian hyperstimulation, including 574 fresh embryo transfer (ET) cycles (Group T1 ) and 47 frozen-thawed embryo transfer (FET) as the first ET cycles (Group C1 ). Logistic regression was used to model the probability of clinical pregnancy rate based on the cycle-specific factors. Results The clinical pregnancy rate was significantly higher in Group C1 than Group T1 [38. 3% ( 18/47 ) vs 22. 1% ( 127/574), P ＜ 0. 05]. Multivariate logistic regression analysis revealed that patient age and ET method were significantly associated with the clinical pregnancy rate. After adjusting for patient age, the clinical pregnancy rate remained significantly higher in Group C1 than Group T1 (OR:2. 107, 95% CI: 1. 128 - 3.939, P ＜0.05 ). Conclusion The use of FET instead of fresh ET may improve the clinical pregnancy rate in low-quality embryo cycles.