CAJ | 학술논문

为了寻找低毒有效的放射增敏剂,观察CGEONA(羧基-苯乙烯基锗倍半氧化物钠盐)对荷瘤小鼠和正常小鼠放射敏感性的影响.放射增敏实验用T-739小鼠,肿瘤模型LA-795肺腺癌,采用肿瘤生长延迟法评价效果;放射防护实验用昆明种小鼠,观察30d存活率和对造血系统的影响.结果表明,CGEONA药物浓度为1/10 LD50时平均放射增敏比为1.4.放射防护实验给药组与对照组相比,存活率以及造血系统指标无显著差异(p＞0.05).表明CGEONA是新型低毒有效放射增敏剂,对照射的正常动物无放射增敏作用,值得进一步研究.
위료심조저독유효적방사증민제,관찰CGEONA(최기-분을희기타배반양화물납염)대하류소서화정상소서방사민감성적영향.방사증민실험용T-739소서,종류모형LA-795폐선암,채용종류생장연지법평개효과;방사방호실험용곤명충소서,관찰30d존활솔화대조혈계통적영향.결과표명,CGEONA약물농도위1/10 LD50시평균방사증민비위1.4.방사방호실험급약조여대조조상비,존활솔이급조혈계통지표무현저차이(p＞0.05).표명CGEONA시신형저독유효방사증민제,대조사적정상동물무방사증민작용,치득진일보연구.
In search for less toxic and more effective radio-sensitizer,the effects of CGEONA(Carboxy-β-phenyl-vinyl-germanium sesquioxide sodium salt)on radio-sensitivity of tumor-bearing mice and normal mice were investigated.radiosensitizing experiment was performed using T-739 mice.The tumor model was LA-795 pulmonary adenocaricinoma,and the effect was assessed using tumor regrowth delay.Radioprotection experiments were performed using Kunming mice.The 30-day survival rate and effects on hemopoietic system were observed.It was shown that the average sensitization enhancement ratio(SER)of CGEONA was 1.4 with 1/10 LD50drug dosage.The radioprotection experiments showed no significant differece between treated mice and control mice for survival rate and hemopoietic system.Thus,CGEONA shows great potential as a new type of radiosensitizer with less toxicity and more effectiveness.It has no radiosensitizing effect onn normal mice and is worthy of further studies.