CAJ | 학술논문

　　目的：探讨辛伐他汀的不良反应特点及其临床表现，为临床合理使用提供参考。方法：通过检索“中国期刊全文数据库”、“万方数据库”等，收集1990-2012年国内医药学期刊发表的辛伐他汀的不良反应文献报道，分别从患者性别与年龄的分布、用药情况、ADR发生时间、ADR累及器官或系统及临床表现、药物相互作用等方面进行分析整理。结果：共检索到57篇相关文献，涉及68例病例，61～70岁患者服用辛伐他汀的不良反应发生率最高。辛伐他汀引起的肌肉损害最为多见，其次为肝损害，其他不良反应散在发生。结论：在临床应用过程中，应关注辛伐他汀引起的不良反应，可以通过对患者用药过程进行监护等措施确保患者用药安全。
　　목적：탐토신벌타정적불량반응특점급기림상표현，위림상합리사용제공삼고。방법：통과검색“중국기간전문수거고”、“만방수거고”등，수집1990-2012년국내의약학기간발표적신벌타정적불량반응문헌보도，분별종환자성별여년령적분포、용약정황、ADR발생시간、ADR루급기관혹계통급림상표현、약물상호작용등방면진행분석정리。결과：공검색도57편상관문헌，섭급68례병례，61～70세환자복용신벌타정적불량반응발생솔최고。신벌타정인기적기육손해최위다견，기차위간손해，기타불량반응산재발생。결론：재림상응용과정중，응관주신벌타정인기적불량반응，가이통과대환자용약과정진행감호등조시학보환자용약안전。
Objective: To investigate the clinical manifestations and characteristics of ADRs induced by simvastatin, so as to provide references for the clinical rational use of simvastatin. Method: Literatures from"Chinese Academic Journal" and "Wanfang Database" between 1990 and 2012 were retrieved and analyzed in respect of patient’s gender and age, medication, occurrence time of ADR, organs or systems involved in ADRs and clinical manifestations. Results: 57 literatures involving 68 cases were retrieved. Highest ADR rates occurred among 61~70 years old patients. Sarcous damage induced by simvastatin was the most common ADR, followed by liver damage. Conclusion: Attention should be paid to the ADRs induced by simvastatin, and close monitoring was necessary for the clinical rational use of simvastatin.