中国现代医学杂志
中國現代醫學雜誌
중국현대의학잡지
CHINA JOURNAL OF MODERN MEDICINE
2007年
2期
134-137
,共4页
乔岐禄%温泉%赵建勋%刘玉村
喬岐祿%溫泉%趙建勛%劉玉村
교기록%온천%조건훈%류옥촌
胆囊癌%胆管癌%β-连环素%细胞周期素D1%Wnt信号传导通路
膽囊癌%膽管癌%β-連環素%細胞週期素D1%Wnt信號傳導通路
담낭암%담관암%β-련배소%세포주기소D1%Wnt신호전도통로
carcinoma of gallbladder%cholangiocarcinoma%β-catenin%cyclin D1%Wnt signaling passway
目的 通过观察胆道肿瘤组织中β-连环素(β-catenin)与细胞周期素D1(cyclinD1)的表达,探讨它们和胆道肿瘤发生、预后的关系.方法 应用免疫组织化学法研究33例胆囊癌,35例胆管癌中β-catenin与cyclinD1的表达特点,并结合临床资料进行统计学分析.结果 10例正常的胆囊和胆管标本中β-catenin与cyclinD1均呈正常表达.而在33例胆囊癌组织中有16例(48.5%)β-catenin的异常表达和18例(54.5%)cyclinD1的过度表达;35例胆管癌组织中存在18例(51.4%)β-catenin的异常表达和16例(45.7%)cyclinD1的过度表达.在胆道恶性肿瘤中,β-catenin的表达异常和cyclinD1的过度表达与TNM分期和/或肿瘤的分化相关,而且β-catenin的异常表达与cyclinD1的过度表达相关(P＜0.05).结论 在胆道恶性肿瘤组织中存在β-catenin的异常表达与cyclinD1的过度表达.β-catenin的异常表达与cyclinD1的过度表达之间的相关性提示,β-catenin/Wnt信号转导途径参与了胆道肿瘤的发生和发展.
目的 通過觀察膽道腫瘤組織中β-連環素(β-catenin)與細胞週期素D1(cyclinD1)的錶達,探討它們和膽道腫瘤髮生、預後的關繫.方法 應用免疫組織化學法研究33例膽囊癌,35例膽管癌中β-catenin與cyclinD1的錶達特點,併結閤臨床資料進行統計學分析.結果 10例正常的膽囊和膽管標本中β-catenin與cyclinD1均呈正常錶達.而在33例膽囊癌組織中有16例(48.5%)β-catenin的異常錶達和18例(54.5%)cyclinD1的過度錶達;35例膽管癌組織中存在18例(51.4%)β-catenin的異常錶達和16例(45.7%)cyclinD1的過度錶達.在膽道噁性腫瘤中,β-catenin的錶達異常和cyclinD1的過度錶達與TNM分期和/或腫瘤的分化相關,而且β-catenin的異常錶達與cyclinD1的過度錶達相關(P＜0.05).結論 在膽道噁性腫瘤組織中存在β-catenin的異常錶達與cyclinD1的過度錶達.β-catenin的異常錶達與cyclinD1的過度錶達之間的相關性提示,β-catenin/Wnt信號轉導途徑參與瞭膽道腫瘤的髮生和髮展.
목적 통과관찰담도종류조직중β-련배소(β-catenin)여세포주기소D1(cyclinD1)적표체,탐토타문화담도종류발생、예후적관계.방법 응용면역조직화학법연구33례담낭암,35례담관암중β-catenin여cyclinD1적표체특점,병결합림상자료진행통계학분석.결과 10례정상적담낭화담관표본중β-catenin여cyclinD1균정정상표체.이재33례담낭암조직중유16례(48.5%)β-catenin적이상표체화18례(54.5%)cyclinD1적과도표체;35례담관암조직중존재18례(51.4%)β-catenin적이상표체화16례(45.7%)cyclinD1적과도표체.재담도악성종류중,β-catenin적표체이상화cyclinD1적과도표체여TNM분기화/혹종류적분화상관,이차β-catenin적이상표체여cyclinD1적과도표체상관(P＜0.05).결론 재담도악성종류조직중존재β-catenin적이상표체여cyclinD1적과도표체.β-catenin적이상표체여cyclinD1적과도표체지간적상관성제시,β-catenin/Wnt신호전도도경삼여료담도종류적발생화발전.
[Objective] To investigate expression of β-catenin and cyclinD1 and its possible role in the tumors' development and progression. [Methods] Expression of β-catenin and cyclinD1 was immunohistochemically studied in gallbladder carcinoma (33 cases), and cholangiocarcinoma (35 cases), respectively. The results were analyzed with clinical-pathological data. [Results] Normal expression of β-catenin and cyclinD1 was found in 10 cases of normal biliary control samples. Abnormal expression of β-catenin and cyclinD1 overexpression was detected in 48.5% (16/33) and 54.5% (18/33) in samples of gallbladder carcinoma respectively. Similarly, abnormal expression of β-catenin and cyclinD1 overexpression were also found in cholangiocarcinoma, 51.4% (18/35) and 45.7% (16/35) respectively.Abnormal expression of β-catenin and cyclinD1 overexpression were related to TNM stages and/or tumor differentiation in these biliary tumors. Furthermore, in both gallbladder carcinoma and cholangiocarcinoma, abnormal β-catenin expression was correlated with cyclinD1 overexpression (P ＜0.05). [ Conclusion] Abnormal expression of β-catenin and cyclinD1 overexpression exist in biliary tumors. Correlation between abnormal expression of β-catenin and cyclinD1 overexpression suggests that WNT/β-catenin signaling pathway plays a role in biliary tumors' development and progression.
