CAJ | 학술논문

目的探讨低脂高糖膳食对中国汉族青年血脂及载脂蛋白的影响.方法我室招募健康在校大学生自愿者56名((22.89±1.80)岁],于7 d平衡膳食后给予低脂高糖膳食6 d,分别在第1 d、8 d、14 d清晨收集受试者人类学指标并抽取空腹静脉血,测定血清甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血糖(GLU)、胰岛素(Insulin)、载脂蛋白A-Ⅰ(Apo A-Ⅰ)、载脂蛋白B-100(Apo B-100)浓度.结果经过6 d低脂高糖膳食以后,健康男性青年血清HDL-C升高,而体质量(Weight)、体重指数(BMI)、TC及LDL-C降低;健康女性青年血清TC、胰岛素升高而TC及LDL-C降低.根据BMl分别将男女受试者分为高、中、低BMI 3组分析发现,尽管某些变化不具有显著性,高、中、低BMI 3组都出现TC及LDL-C降低;男性低BMI和高BMI组出现血清HDL-C及Ape A-Ⅰ显著升高,其它各组膳食前后变化差异无统计学意义.血清TG升高只在女性低BMI和中BMI组中出现.结论不同性别、BMI的健康青年低脂高糖膳食后的血脂及载脂蛋白改变不相同,但均没有发现HDL-C显著降低.
목적 탐토저지고당선식대중국한족청년혈지급재지단백적영향.방법 아실초모건강재교대학생자원자56명((22.89±1.80)세],우7 d평형선식후급여저지고당선식6 d,분별재제1 d、8 d、14 d청신수집수시자인류학지표병추취공복정맥혈,측정혈청감유삼지(TG)、총담고순(TC)、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C)、혈당(GLU)、 이도소(Insulin)、재지단백A-Ⅰ(Apo A-Ⅰ)、재지단백B-100(Apo B-100)농도.결과경과6 d저지고당선식이후,건강남성청년혈청HDL-C승고,이체질량(Weight)、체중지수(BMI)、TC급LDL-C강저;건강녀성청년혈청TC、이도소승고이TC급LDL-C강저.근거BMl분별장남녀수시자분위고、중、저BMI 3조분석발현,진관모사변화불구유현저성,고、중、저BMI 3조도출현TC급LDL-C강저;남성저BMI화고BMI조출현혈청HDL-C급Ape A-Ⅰ현저승고,기타각조선식전후변화차이무통계학의의.혈청TG승고지재녀성저BMI화중BMI조중출현.결론불동성별、BMI적건강청년저지고당선식후적혈지급재지단백개변불상동,단균몰유발현HDL-C현저강저.
More studies are needed on the hyperyriacylglycerolemic effects of low fat and high carbohydrate (LF-HC) diet in young population, especially Chinese who generally have a diet containing lower fat and higher carbohydrate. To test them in a young Chinese Han population, 56 healthy subjects (22.89±1.80) years were given regular diet of 31% fat and 54% carbohy-drate for 7 days, followed by LF-HC diet of 15% fat and 70% carbohydrate for 6 days, without total energy restriction. After the LF-HC diet, the male experienced an increase of high density lipoprutein (HDL) cholesterol and decreases of weight, body mass index (BMI), total cholesterol (TC), and LDL (low density lipoprotein) cholesterol (P < 0.05). The female experienced in-creased serum triacylglycerol and insulin, and decreased TC and LDL cholesterol (P < 0.05). When BMI was taken into account,all the subjects with low, medium, or high BMI experienced decreases of TC and LDL cholesterol although some changes were not significant. No significant decrease of HDL cholesterol was found, while significantly increased HDL cholesterol and apolipoprotein A-Ⅰ (apo A- Ⅰ) were found in the male subjects with low or high BMI (P < 0.05). Significant increase of triacylglycerol was observed only in the female subjects with low or medium BMI. In conclusion, subjects with different BMI and gender have different triacylglycerol and HDL cholesterol responses to LF-HC diets, and significant increase of HDL cholesterol and apolipoprotein A- Ⅰ were observed in some young male subjects.