CAJ | 학술논문

腺病毒栽体具有高效传递和表达基因的能力(尤其是在体外),在过去的15年里已经得到充分地证实.腺病毒载体由于宿主范围广泛和对人体的低致病性、病毒颗粒比较稳定、基因组较少发生重排等优点,已经成为最常用的痛毒载体之一.但由于细胞的靶向性和宿主的免疫反应限制了腺病毒载体的应用和发展,为此,对腺病毒载体进行了不断改进和完善,其潜在的应用价值也得到了广泛关注.现就对腺病毒载体的特点,改进和应用方面的研究进展综述如下.
선병독재체구유고효전체화표체기인적능력(우기시재체외),재과거적15년리이경득도충분지증실.선병독재체유우숙주범위엄범화대인체적저치병성、병독과립비교은정、기인조교소발생중배등우점,이경성위최상용적통독재체지일.단유우세포적파향성화숙주적면역반응한제료선병독재체적응용화발전,위차,대선병독재체진행료불단개진화완선,기잠재적응용개치야득도료엄범관주.현취대선병독재체적특점,개진화응용방면적연구진전종술여하.
It has been confirmed in the past 15 years that adenovirus vector can efficiently transfer and express genes (especially in vitro).Adenovirus vector has become one of the most commonly used vectors because of its wide host spectrum,low pathogenicity,stable virus particle and rare gene rearrangements.Because targeted cells and host immune response limit the application and development of adenovirus vector,the adenovirus vector has been constantly improved and perfected.Therefore,its potential applications have also been widely concerned.This paper reviewed research progress from the aspects of characteristics,improvement and application of adenovirus vector.