CAJ | 학술논문

目的探讨综合治疗联合早期50％硫酸镁湿敷,对儿童蝮蛇咬伤患者的治疗效果及作用机制.方法随机(随机数字法)选择2009年5月至2011年5月急诊科儿童蝮蛇咬伤患者61例,分为治疗组(31例)和对照组(30例).治疗组在综合治疗的基础上早期联用50％硫酸镁纱布湿敷肿胀部位,外用绷带包扎,1次/d,纱布干燥后再用生理盐水喷湿一次；对照组仅只进行综合治疗.两组于入院治疗前和治疗后第1、3、5天,记录两组心肌酶学及患肢标记肿胀部位周长测量差值变化并进行成组t检验,一周治愈率的比较进行x2检验分析.结果两组儿童蝮蛇咬伤患者治疗前基本临床特征差异无统计学意义(P＞0.05),具有可比性.治疗后心肌酶学和肿胀肢体周长下降值比较(P＜0.05),两组一周治愈率分别为80.5％和56.67％,差异具有统计学意义(P＜0.05).结论儿童蝮蛇咬伤患者综合治疗联合50％硫酸镁湿敷,可有效减轻患肢因中毒肿胀引起的组织损伤,促使患肢肿胀消退及功能恢复,缩短治愈时间和防止并发症.
목적 탐토종합치료연합조기50％류산미습부,대인동복사교상환자적치료효과급작용궤제.방법 수궤(수궤수자법)선택2009년5월지2011년5월급진과인동복사교상환자61례,분위치료조(31례)화대조조(30례).치료조재종합치료적기출상조기련용50％류산미사포습부종창부위,외용붕대포찰,1차/d,사포간조후재용생리염수분습일차；대조조부지진행종합치료.량조우입원치료전화치료후제1、3、5천,기록량조심기매학급환지표기종창부위주장측량차치변화병진행성조t검험,일주치유솔적비교진행x2검험분석.결과 량조인동복사교상환자치료전기본림상특정차이무통계학의의(P＞0.05),구유가비성.치료후심기매학화종창지체주장하강치비교(P＜0.05),량조일주치유솔분별위80.5％화56.67％,차이구유통계학의의(P＜0.05).결론 인동복사교상환자종합치료연합50％류산미습부,가유효감경환지인중독종창인기적조직손상,촉사환지종창소퇴급공능회복,축단치유시간화방지병발증.
Objective To explore the mechanism and therapeutic effects of wet dressing with 50％ magnesium sulfate ( MgSO4 ) as a part of comprehensive treatment for wound resulted from pit viper bites in children.Methods A total of 61 children with pit-viper-bitten wound enrolled from May 2009 through May 2011 were divided into two groups,namely the comprehensive treatment group (n =31 cases) and the conventional treatment group (n =30 eases). In the comprehensive treatment group,50％ magnesium sulfate wet dressing applied to the swelling parts of body in the early stage in addition to the conventional treatment and topically bandaged once a day keeping wet with spraying saline on the top of dressing.Before the treatment and on the 1st day,the 3rd day and the 5th day of treatment,the values of myocardial enzyme and the circumference of swelling parts were recorded,and the differences were analyzed by t- test.The differences in rate of wound healing in one week between two groups were analyzed by chi-square test.Results Before the treatment,there was no statistical difference in clinical features between the two groups with different modes of treatment for the viper-bitten children (P ＞ 0.05 ). During comprehensive treatment,the values of myocardial enzyme and the circumference of swelling parts decreased more markedly than those in conventional treatment group ( P ＜ 0.05 ).The rates of wound healing in one week of two groups were 80.5％ and 56.6％ respectively.Conclusions The comprehensive treatment with adjuvant of 50％ MgSO4 for the viper-bitten children can effectively reduce the tissue damage caused by venom,and the swelling as well,restoring function of body and shortening the time for wound healing and preventing complications.