中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2011年
2期
105-107
,共3页
杨涛%李玉娟%王寿平%车月娟%彭书崚
楊濤%李玉娟%王壽平%車月娟%彭書崚
양도%리옥연%왕수평%차월연%팽서릉
脑源性神经营养因子%感觉神经%病理性疼痛
腦源性神經營養因子%感覺神經%病理性疼痛
뇌원성신경영양인자%감각신경%병이성동통
Brain-derived neurotrophic factor%Sensory nerve%Neuropathic pain
目的 观察剪断大鼠的不同感觉神经分支引起的疼痛行为学表现及脑源性神经营养因子(BDNF)在其中的作用.方法 按随机数字表法将24只大鼠分为3组:SUR组,GS组和SHAM组,每组各8只,分别进行剪断Sural、GS神经和假手术.观察3组L5DRG和脊髓背角的BDNF表达情况及损伤的细胞类型.结果 GS组大鼠术后同侧后肢机械刺激50%缩足阈值较基础值和SHAM组显著下降(P<0.01),热刺激撤足持续时间显著延长(P<0.01),SUR组则无变化(P>0.05).GS组L5DRG中BDNF阳性神经元比率[(37.87±4.23)%]和脊髓的BDNF阳性面积百分比[(21.9±3.1)%]较SHAM组增高[(分别为(17.31±2.12)%],(12.6±1.3)%],差异具有显著性(P<0.01);而SUR组与SHAM组之间无统计学差异(P>0.05).GS组表达BDNF的FG阳性神经元较SUR组明显增高(P<0.01)[分别为(81.5%±3.8)%,(6.4±0.9)%];GS组中NF200与FG共染神经元占NF200阳性神经元的百分比较SUR组显著增高(P<0.01)[分别为(47.7±1.8)%和(26.7±2.3)%].结论 切断骨骼肌的感觉神经会产生痛觉过敏,而切断皮肤的感觉神经则不会.不同类型神经元受损,以及DRG和脊髓背角的BDNF表达差异是导致这种痛觉差异的重要原因.
目的 觀察剪斷大鼠的不同感覺神經分支引起的疼痛行為學錶現及腦源性神經營養因子(BDNF)在其中的作用.方法 按隨機數字錶法將24隻大鼠分為3組:SUR組,GS組和SHAM組,每組各8隻,分彆進行剪斷Sural、GS神經和假手術.觀察3組L5DRG和脊髓揹角的BDNF錶達情況及損傷的細胞類型.結果 GS組大鼠術後同側後肢機械刺激50%縮足閾值較基礎值和SHAM組顯著下降(P<0.01),熱刺激撤足持續時間顯著延長(P<0.01),SUR組則無變化(P>0.05).GS組L5DRG中BDNF暘性神經元比率[(37.87±4.23)%]和脊髓的BDNF暘性麵積百分比[(21.9±3.1)%]較SHAM組增高[(分彆為(17.31±2.12)%],(12.6±1.3)%],差異具有顯著性(P<0.01);而SUR組與SHAM組之間無統計學差異(P>0.05).GS組錶達BDNF的FG暘性神經元較SUR組明顯增高(P<0.01)[分彆為(81.5%±3.8)%,(6.4±0.9)%];GS組中NF200與FG共染神經元佔NF200暘性神經元的百分比較SUR組顯著增高(P<0.01)[分彆為(47.7±1.8)%和(26.7±2.3)%].結論 切斷骨骼肌的感覺神經會產生痛覺過敏,而切斷皮膚的感覺神經則不會.不同類型神經元受損,以及DRG和脊髓揹角的BDNF錶達差異是導緻這種痛覺差異的重要原因.
목적 관찰전단대서적불동감각신경분지인기적동통행위학표현급뇌원성신경영양인자(BDNF)재기중적작용.방법 안수궤수자표법장24지대서분위3조:SUR조,GS조화SHAM조,매조각8지,분별진행전단Sural、GS신경화가수술.관찰3조L5DRG화척수배각적BDNF표체정황급손상적세포류형.결과 GS조대서술후동측후지궤계자격50%축족역치교기출치화SHAM조현저하강(P<0.01),열자격철족지속시간현저연장(P<0.01),SUR조칙무변화(P>0.05).GS조L5DRG중BDNF양성신경원비솔[(37.87±4.23)%]화척수적BDNF양성면적백분비[(21.9±3.1)%]교SHAM조증고[(분별위(17.31±2.12)%],(12.6±1.3)%],차이구유현저성(P<0.01);이SUR조여SHAM조지간무통계학차이(P>0.05).GS조표체BDNF적FG양성신경원교SUR조명현증고(P<0.01)[분별위(81.5%±3.8)%,(6.4±0.9)%];GS조중NF200여FG공염신경원점NF200양성신경원적백분비교SUR조현저증고(P<0.01)[분별위(47.7±1.8)%화(26.7±2.3)%].결론 절단골격기적감각신경회산생통각과민,이절단피부적감각신경칙불회.불동류형신경원수손,이급DRG화척수배각적BDNF표체차이시도치저충통각차이적중요원인.
Objective To observe the pain behavioral performance of rats that different sensory nerve fibers were transected,and examine the expression of brain-derived neurotrophic factor(BDNF) in these models.Methods Twenty-four rats were divided into three groups according to random number table method:SUR group,GS group and SHAM group, which received sural nerve transection, gastrocnemius-soleus nerve transection or sham operation respectively.There were 8 rats in every group.The expression of BDNF in the lumbar 5 DRG and spinal dorsal horn were detected,and the types of damaged cells were also observed.Results In GS group, 50% paw-withdrawal thresholds were significantly decreased on the ipsilateral hind paw compared with baseline and with those in SHAM group,and the paw-withdrawal durations in response to the thermal stimulus increased significantly (P<0.01 =.In contrast, no change was found in SUR group(P>0.05 ).The expression of BDNF in the lumbar 5 DRG ( (37.87 ± 4.23 ) % ) and spinal dorsal horn ( (21.9 ± 3.1 ) % ) was significantly higher in GS group than in SHAM group( ( 17.31 ± 2.12 ) %, ( 12.6 ± 1.3 ) % ), and no significant difference was found between SUR and SHAM groups(P>0.05 ).FG opposite cells which also expressed BDNF in GS group were more than those in SUR group ( (47.7 ± 1.8) % and (26.7 ± 2.3 ) % ) (P < 0.01 =.The percentage in N200 and FG double positive cells to N200 positive cells in GS group was significantly increased in GS group than those in SUR group ( (47.7 ±1.8 ) %, (26.7 ± 2.3 ) % ) (P < 0.01 =.Conclusion The data suggest that injury of the sensory nerve innervating skin does not produce hyperalgesia, but injury of the sensory nerve innervating muscle does.Different kinds of neuron were damaged and the differences of BDNF expression is essential for this difference.