中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2008年
9期
1459-1460
,共2页
肺疾病,慢性阻塞性%真菌病%危险因素
肺疾病,慢性阻塞性%真菌病%危險因素
폐질병,만성조새성%진균병%위험인소
Pulmonary diseas,Chronic obstructive%Mycoses%Risk factors
目的 分析慢性阻塞性肺疾病(COPD)患者合并肺部真菌感染的危险因素及其免疫状态.方法 选择COPD合并真菌感染55例,COPD无合并真菌感染67例,健康人54例作为对照,检测其外周血T淋巴细胞亚群(TLS)水平并进行比较.COPD患者合并肺部真菌感染的危险因素采用单因素分析.结果 真菌感染以白色念珠菌感染为主,COPD合并真菌感染组和COPD无合并真菌感染组CD3、CD4和CD4/CD8比值均显著低于对照组(P＜0.05),且COPD合并真菌感染组CD3、CD4明显低于COPD无合并真菌感染组(P＜0.05).结论 合理使用抗菌药物及糖皮质激素、抗真菌、机械通气治疗,有效提高机体免疫水平,治疗糖尿病、呼吸衰竭等基础病是降低COPD并发肺部真菌感染的重要措施.
目的 分析慢性阻塞性肺疾病(COPD)患者閤併肺部真菌感染的危險因素及其免疫狀態.方法 選擇COPD閤併真菌感染55例,COPD無閤併真菌感染67例,健康人54例作為對照,檢測其外週血T淋巴細胞亞群(TLS)水平併進行比較.COPD患者閤併肺部真菌感染的危險因素採用單因素分析.結果 真菌感染以白色唸珠菌感染為主,COPD閤併真菌感染組和COPD無閤併真菌感染組CD3、CD4和CD4/CD8比值均顯著低于對照組(P＜0.05),且COPD閤併真菌感染組CD3、CD4明顯低于COPD無閤併真菌感染組(P＜0.05).結論 閤理使用抗菌藥物及糖皮質激素、抗真菌、機械通氣治療,有效提高機體免疫水平,治療糖尿病、呼吸衰竭等基礎病是降低COPD併髮肺部真菌感染的重要措施.
목적 분석만성조새성폐질병(COPD)환자합병폐부진균감염적위험인소급기면역상태.방법 선택COPD합병진균감염55례,COPD무합병진균감염67례,건강인54례작위대조,검측기외주혈T림파세포아군(TLS)수평병진행비교.COPD환자합병폐부진균감염적위험인소채용단인소분석.결과 진균감염이백색념주균감염위주,COPD합병진균감염조화COPD무합병진균감염조CD3、CD4화CD4/CD8비치균현저저우대조조(P＜0.05),차COPD합병진균감염조CD3、CD4명현저우COPD무합병진균감염조(P＜0.05).결론 합리사용항균약물급당피질격소、항진균、궤계통기치료,유효제고궤체면역수평,치료당뇨병、호흡쇠갈등기출병시강저COPD병발폐부진균감염적중요조시.
Objective To investigate the risk factors and the immune functions for noeocomial palmonary fungal infection (PFI) in COPD patients.Methods The data of 55 cases of nosocomial PFI were analyzed,and examined the level of T Lymphocyte Subsets (TLS) in peripheral blood from 67 cases COPD,then compared with 54 healthy donors.Results Nosocomial pulmonary fungal infection Candida Albicans was ranked the first pathogen.CD3 and CD4 of COPD with PFI were significantly ower than COPD and healthy donors(P＜0.05).Conclusions We should improve the immunity of patients in the process of therapy.We should reasonable use of bread spectrum antibiotics and corticosteroids in order to reduce incidence of pulmonary fungal infection.
