中国医药
中國醫藥
중국의약
CHINA MEDICINE
2011年
7期
816-817
,共2页
彭裕辉%方裕森%许镒洧%陈伟正
彭裕輝%方裕森%許鎰洧%陳偉正
팽유휘%방유삼%허일유%진위정
食管鳞状细胞癌%潮汕地区%细胞角蛋白19片段%癌胚抗原
食管鱗狀細胞癌%潮汕地區%細胞角蛋白19片段%癌胚抗原
식관린상세포암%조산지구%세포각단백19편단%암배항원
]Esophageal Squamous Cell Carcinoma%Chaoshan area%Cytokeratin 19 fragments%Carcinoembryonic antigen
目的 探讨细胞角蛋白19片段(CYFRA21-1)在潮汕地区食管鳞状细胞癌诊断中的应用价值.方法 采用电化学发光法分别检测健康对照组(30例)和食管鳞状细胞癌患者(90例)术前、术后第10天血清中CYFRA21-1和癌胚抗原(CEA)浓度,并对患者进行随访,复发者再检测血清中CYFRA21-1和CEA浓度.结果 食管癌组术前CYFRA21-1和CEA水平明显高于对照组[分别为(5.13±2.75)μg/L比(1.61±0.70)μg/L,(3.14±1.60)μg/L比(1.93±0.74)μg/L,均P<0.05].食管癌组术前CYFRA21-1和CEA水平高于术后第10天[分别为(5.13±2.75)μg/L比(2.44±0.65)μg/L,(3.14±1.60)μg/L比(2.55±0.92)μg/L],差异有统计学意义(均P<0.05).患者术前血清CYFRA21-1阳性率(58.9%,53/90)高于CEA(25.6%,23/90),差异有统计学意义(χ2=18.00,P<0.05);复发者血清CYFRA21-1阳性率(72.5%,29/40)高于CEA(32.5%,13/40),差异有统计学意义(χ2=12.50,P<0.05).结论 血清CYFRA21-1是食管鳞状细胞癌诊断和判断复发的辅助指标.
目的 探討細胞角蛋白19片段(CYFRA21-1)在潮汕地區食管鱗狀細胞癌診斷中的應用價值.方法 採用電化學髮光法分彆檢測健康對照組(30例)和食管鱗狀細胞癌患者(90例)術前、術後第10天血清中CYFRA21-1和癌胚抗原(CEA)濃度,併對患者進行隨訪,複髮者再檢測血清中CYFRA21-1和CEA濃度.結果 食管癌組術前CYFRA21-1和CEA水平明顯高于對照組[分彆為(5.13±2.75)μg/L比(1.61±0.70)μg/L,(3.14±1.60)μg/L比(1.93±0.74)μg/L,均P<0.05].食管癌組術前CYFRA21-1和CEA水平高于術後第10天[分彆為(5.13±2.75)μg/L比(2.44±0.65)μg/L,(3.14±1.60)μg/L比(2.55±0.92)μg/L],差異有統計學意義(均P<0.05).患者術前血清CYFRA21-1暘性率(58.9%,53/90)高于CEA(25.6%,23/90),差異有統計學意義(χ2=18.00,P<0.05);複髮者血清CYFRA21-1暘性率(72.5%,29/40)高于CEA(32.5%,13/40),差異有統計學意義(χ2=12.50,P<0.05).結論 血清CYFRA21-1是食管鱗狀細胞癌診斷和判斷複髮的輔助指標.
목적 탐토세포각단백19편단(CYFRA21-1)재조산지구식관린상세포암진단중적응용개치.방법 채용전화학발광법분별검측건강대조조(30례)화식관린상세포암환자(90례)술전、술후제10천혈청중CYFRA21-1화암배항원(CEA)농도,병대환자진행수방,복발자재검측혈청중CYFRA21-1화CEA농도.결과 식관암조술전CYFRA21-1화CEA수평명현고우대조조[분별위(5.13±2.75)μg/L비(1.61±0.70)μg/L,(3.14±1.60)μg/L비(1.93±0.74)μg/L,균P<0.05].식관암조술전CYFRA21-1화CEA수평고우술후제10천[분별위(5.13±2.75)μg/L비(2.44±0.65)μg/L,(3.14±1.60)μg/L비(2.55±0.92)μg/L],차이유통계학의의(균P<0.05).환자술전혈청CYFRA21-1양성솔(58.9%,53/90)고우CEA(25.6%,23/90),차이유통계학의의(χ2=18.00,P<0.05);복발자혈청CYFRA21-1양성솔(72.5%,29/40)고우CEA(32.5%,13/40),차이유통계학의의(χ2=12.50,P<0.05).결론 혈청CYFRA21-1시식관린상세포암진단화판단복발적보조지표.
Objective To investigate the clinical significance of cytokeratin 19 fragments (CYFRA21-1)in patients with esophageal squamous cell carcinoma in Chaoshan area.Methods The electrochemiluminescence (ECLIA) was used to detect the serum concentrations of CYFRA21-1 and carcinoembryonic antigen(CEA)in the healthy controls and the patients with esophageal squamous cell carcinoma (ESCC) before surgery and 10 days after analyzed.Resuits In Chaoshan area.the serum levels of CYFRA21-1 and CEA in patients with ESCC were obviously higher before surgery than that 10 days after sugery(P<0.05).The positive rate of CYFRA21-1 before surgery(58.9%,53/90)was higher than that of CEA(25.6%,23/90),with statistical significance(χ2=18.00,P<0.05).The positive rate of CYFRA21-1(72.5%,29/40)in the recurrence of esophageal tumors was higher than that of CEA(32.5%,13/40),with statistical significance(χ2=12.50,P<0.05).Conclusion Serum CYFRA21-1 is the secondary indicator of the diagnosis and recurrence of ESCC.
