CAJ | 학술논문

目的超重和肥胖已成为影响青少年健康的关键问题.本研究探讨饮食及运动干预对青少年体内氧化应激状态的影响.方法 124名受试者中的93名超重及肥胖青少年年龄(13.6±0.7)岁,体重指数(BMI 22.4 ～ 34.1 kg/m2)随机分为四组:饮食干预组(D)、运动干预组(E)、饮食运动干预组(DE)、超重及肥胖对照组(O).饮食方案根据研究对象的年龄及理想体重制定；运动干预为放学后1h中等强度运动,每周4次.干预周期为10周,干预前后分别进行人体测量、身体成分、代谢及氧化应激等指标检测.31名正常体重者为对照组.结果超重及肥胖组的空腹血糖、TC、LDL-C和MDA水平明显高于正常体重组(P＜0.05),SOD水平低于正常体重组(P＜0.05)；MDA水平与体重、BMI、TC、LDL-C呈正相关(R=0.209,0.228,0.274,0.263,P＜0.05),SOD与体重及BMI呈负相关(R=-0.334,-0.362,P＜0.05)；干预后D、E、DE组BMI、腰围、全身脂肪显著下降(P＜0.05),D和E组的MDA水平下降(P＜0.05)；两个运动干预组的TC和LDL-C下降亦达统计学差异(P＜0.05).结论超重青少年在糖脂代谢正常阶段体内即存在氧化应激失衡状态.为期10周的饮食和(或)运动的生活方式干预在改善青少年超重状态、调节血脂水平的同时,还可显著降低其体内的氧化应激水平.
목적 초중화비반이성위영향청소년건강적관건문제.본연구탐토음식급운동간예대청소년체내양화응격상태적영향.방법 124명수시자중적93명초중급비반청소년년령(13.6±0.7)세,체중지수(BMI 22.4 ～ 34.1 kg/m2)수궤분위사조:음식간예조(D)、운동간예조(E)、음식운동간예조(DE)、초중급비반대조조(O).음식방안근거연구대상적년령급이상체중제정；운동간예위방학후1h중등강도운동,매주4차.간예주기위10주,간예전후분별진행인체측량、신체성분、대사급양화응격등지표검측.31명정상체중자위대조조.결과 초중급비반조적공복혈당、TC、LDL-C화MDA수평명현고우정상체중조(P＜0.05),SOD수평저우정상체중조(P＜0.05)；MDA수평여체중、BMI、TC、LDL-C정정상관(R=0.209,0.228,0.274,0.263,P＜0.05),SOD여체중급BMI정부상관(R=-0.334,-0.362,P＜0.05)；간예후D、E、DE조BMI、요위、전신지방현저하강(P＜0.05),D화E조적MDA수평하강(P＜0.05)；량개운동간예조적TC화LDL-C하강역체통계학차이(P＜0.05).결론 초중청소년재당지대사정상계단체내즉존재양화응격실형상태.위기10주적음식화(혹)운동적생활방식간예재개선청소년초중상태、조절혈지수평적동시,환가현저강저기체내적양화응격수평.
Objective To explore the effects of diet and/or exercise intervention on oxidative stress of overweight or obese adolescents.Methods Thirty-one adolescents with normal body weight(normal control group)and 93 overweight or obese adolescents(average age(13.6 ±0.7)years; body mass index (BMI)22.4 to 34.1 kg/m2)were enrolled in this study.The overweight or obese participants were then randomly assigned to the diet group(group A),exercise group(group B),diet plus exercise group(group C),and non-intervention group(group D).Individualized caloric intake was carried out.One-hour afterschool exercise was performed once per day,4 days per week for 10 weeks.Changes of anthropometry,body composition,and metabolic biomarkers were determined.Results Compared to the normal control group,serum levels of fasting glucose,total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and malondialdehyde(M DA)of the in overweight group were significant increased(all P ＜ 0.05),although the level of SOD was significant decreased(P ＜ 0.05).Serum MDA level was positively correlated with bodyweight,BMI,TC,and LDL-C(R values were 0.209,0.228,0.274,and 0.263,respectively ; all P ＜0.05),and serum SOD level was negatively correlated with bodyweight and BMI(R values were-0.334 and-0.362,respectively ; both P ＜ 0.05).Group A,B and C showed a significant decrease in BMI,waist circumference and body fat after the intervention(all P ＜ 0.05).The level of MDA was significantly decreased after the intervention in group A and B(both P ＜ 0.05); the levels of TC and LDL-C were significantly decreased in group B and C(both P ＜ 0.05).Conclusion:Oxidative stress could have existed in overweight adolescents even when their serum glucose and lipid profiles are at a normal level.Ten-week diet and/or exercise intervention may contribute to improved body weight control,lipid metabolism,and oxidative stress response in this population.