国际遗传学杂志
國際遺傳學雜誌
국제유전학잡지
INTERNATIONAL JOURNAL OF GENETICS
2010年
4期
198-200
,共3页
谷胱甘肽硫转移酶M1%多态性%基因%低出生体重
穀胱甘肽硫轉移酶M1%多態性%基因%低齣生體重
곡광감태류전이매M1%다태성%기인%저출생체중
Glutathione S-transferases M1%Polymorphism%Gene%Low birth weight
目的 为探讨谷胱甘肽硫转移酶M1基因(glutathione S-transferases M1 gene,GSTM1)多态性与低出生体重的关系.方法 采用病例对照研究方法,收集母亲和新生儿资料,用等位基因特异性PCR方法分析母亲GSTM1基因型.应用Logistic回归,对母体GSTM1基因与新生儿低出生体重的相关性进行分析.结果 GSTM1缺失基因型对低出生体重影响未显示显著相关性[OR=1.553,95%CI(0.7052.863);OR=2.016,95%CI(10.961 2.942)].结论 母亲GSTM1基因多态性与低出生体重无相关性.
目的 為探討穀胱甘肽硫轉移酶M1基因(glutathione S-transferases M1 gene,GSTM1)多態性與低齣生體重的關繫.方法 採用病例對照研究方法,收集母親和新生兒資料,用等位基因特異性PCR方法分析母親GSTM1基因型.應用Logistic迴歸,對母體GSTM1基因與新生兒低齣生體重的相關性進行分析.結果 GSTM1缺失基因型對低齣生體重影響未顯示顯著相關性[OR=1.553,95%CI(0.7052.863);OR=2.016,95%CI(10.961 2.942)].結論 母親GSTM1基因多態性與低齣生體重無相關性.
목적 위탐토곡광감태류전이매M1기인(glutathione S-transferases M1 gene,GSTM1)다태성여저출생체중적관계.방법 채용병례대조연구방법,수집모친화신생인자료,용등위기인특이성PCR방법분석모친GSTM1기인형.응용Logistic회귀,대모체GSTM1기인여신생인저출생체중적상관성진행분석.결과 GSTM1결실기인형대저출생체중영향미현시현저상관성[OR=1.553,95%CI(0.7052.863);OR=2.016,95%CI(10.961 2.942)].결론 모친GSTM1기인다태성여저출생체중무상관성.
Objective To evaluate the association between maternal genetic polymorophisms of the glutathione S-transferases Ml gene ( GSTM1 ) and neonatal low birth weights. Methods Case-control study method was used, and data of mothers and infants were collected from medical record. Allele specific PCR method was applied to examine GSTM1 polymorphisms and logistic regression was used to analyze the association. Results No significant correlation was found between maternal polymorphisms of GSTMX and neonatal low birth weight [OR = 1. 553, 95 % C/(0. 705 · 2. 863); OR = 2. 016, 95 % CI(0.961 o 2.942), respectively]. Conclusion There is no significant correlation or association between maternal genetic polymorphisms of GSTMX gene and neonatal low birth weight.
