CAJ | 학술논문

目的观察术前新辅助化疗治疗局部晚期宫颈癌患者的治疗效果.方法 2006年8月至2010年7月选择紫杉醇联合顺铂化疗方案对海南医学院附属医院62例Ⅰh2～Ⅱb期宫颈癌患者进行2～3个疗程的新辅助化疗,通过观察患者病灶大小的改变、手术情况和术后病理反应等对治疗效果进行评价.结果化疗后总有效率为90.32％ (56/62),完全缓解30.65％ (19/62).肿瘤直径较化疗前有不同程度缩小,差异有统计学意义(P＜0.05).有效的56例患者化疗疗程结束后顺利完成宫颈癌根治术,手术切除率为90.32％.在术后切除的标本中见癌组织周围明显化疗反应和大量淋巴细胞浸润者50例,术后淋巴结阳性者3例,宫旁浸润者2例,脉管癌栓者2例.结论术前新辅助化疗治疗宫颈癌可以缩减局部肿瘤病灶,宫旁组织弹性变软,降低肿瘤的分期,提高手术治疗效果.
목적 관찰술전신보조화료치료국부만기궁경암환자적치료효과.방법 2006년8월지2010년7월선택자삼순연합순박화료방안대해남의학원부속의원62례Ⅰh2～Ⅱb기궁경암환자진행2～3개료정적신보조화료,통과관찰환자병조대소적개변、수술정황화술후병리반응등대치료효과진행평개.결과 화료후총유효솔위90.32％ (56/62),완전완해30.65％ (19/62).종류직경교화료전유불동정도축소,차이유통계학의의(P＜0.05).유효적56례환자화료료정결속후순리완성궁경암근치술,수술절제솔위90.32％.재술후절제적표본중견암조직주위명현화료반응화대량림파세포침윤자50례,술후림파결양성자3례,궁방침윤자2례,맥관암전자2례.결론 술전신보조화료치료궁경암가이축감국부종류병조,궁방조직탄성변연,강저종류적분기,제고수술치료효과.
Objective To explore the clinical curative effects of preoperative neoadjuvant chemotherapy (NACT) on locally advanced cervical cancer.Methods A total of 62 patients of stage Ⅰ b2-Ⅱ b cervical cancer received neoadjuvant chemotherapy of paclitaxel plus cisplatin for 2-3 courses.The clinical curative effects were evaluated according to the changes of lesion size,intraoperative conditions and postoperative pathological reactions.Results The overall response rate was 90.32％ (56/62) and the complete response rate 30.65％ (19/62).The tumor volumes decreased after NACT.The differences were significant (P ＜ 0.05).After NACT,56 patients undergoing radical hysterectomy recovered smoothly.The surgical resection rate was 90.32％.Chemotherapeutic reactions of cancerous tissue and a large number of infiltrated lymphocytes were seen in 50 cases.Lymph nodes were positive in 3 cases.There were parametrial invasion ( n =2) and vascular tumor emboli (n =2).Conclusion Preoperative neoadjuvant chemotherapy is efficacious in cervical cancer.The parametrium becomes softer and the tumor staging decreases.