CAJ | 학술논문

目的探讨XIAP蛋白在非霍奇金淋巴瘤(NHL)中的表达及其临床病理意义.方法应用TdT介导的dUTP缺口末端标记(TUNEL)技术和免疫组织化学SP法,检测79例NHL和20例良性淋巴结病变中的肿瘤细胞凋亡及XIAP蛋白的表达水平.结果 39.2%(31/79)NHL表达XIAP蛋白,而在15%(3/20)良性淋巴结病变中弱阳性表达,两者差异有统计学意义(P＜0.05);XIAP在NHL中的表达与年龄、性别及免疫表型无关(P＞0.05);XIAP阳性表达患者的平均生存时间明显短于无表达患者(P＜0.05).结论 XIAP蛋白可能通过凋亡抑制功能在NHL的发生进展中有一定作用,并可作为判断NHL预后的参考指标.
목적 탐토XIAP단백재비곽기금림파류(NHL)중적표체급기림상병리의의.방법 응용TdT개도적dUTP결구말단표기(TUNEL)기술화면역조직화학SP법,검측79례NHL화20례량성림파결병변중적종류세포조망급XIAP단백적표체수평.결과 39.2%(31/79)NHL표체XIAP단백,이재15%(3/20)량성림파결병변중약양성표체,량자차이유통계학의의(P＜0.05);XIAP재NHL중적표체여년령、성별급면역표형무관(P＞0.05);XIAP양성표체환자적평균생존시간명현단우무표체환자(P＜0.05).결론 XIAP단백가능통과조망억제공능재NHL적발생진전중유일정작용,병가작위판단NHL예후적삼고지표.
Objective To investigate the expression of XIAP and its significance in non-Hodgkin's lymphomas.Methods Tdt-mediate dUTP nick end labeling(TUNEL)and immunohistoehemistry were used to study cell apoptosis and expression of XIAP in 79 non-Hodgkin's lymphoma samples and 20 benign lymph node pathological changes.Results XIAP was positive in 31 of 79(39.2%)cases of non-Hodgkin's lymphomas,but its expression was detected only in 3 of 20 cases of benign lymph node lesions(P＜0.05).The expression of XIAP was irrelevant to age,gender and immune phenotype of non-Hodgkin's lymphoma (P＞0.05).Furthermore,the mean survival period was significantly shorter in patients' expressing XIAP as compared with the XIAP-negative group.Conclusions Apoptosis inhibition by overexpression of XIAP might be involved in the onset and progress of non-Hodgkin's lymphoma.The expression of XIAP may be used as a reference index for evaluating prognosis of non-Hodgkin's lymphoma.