CAJ | 학술논문

首次报道柔弱短指软珊瑚(Sinula ria tenella Li.)的化学成分。从中国南海采集的柔弱短指软珊瑚中分离得到5个西松烯二萜内酯。根据波谱数据分析，推导出它们的结构：dihydroflexibilide(1),flxibilide(2)sinulariolide(3),(1R，4R,5R,8S,9S,12S,13S)-9-acetoxy-5,8∶12,13-diepoxy-cembr-15(17 )-en-16,4-olide(4)和(1R,4R,5S 12S,13S)-5-acetoxy -12,13-epoxy-cembr-8E,15(17)-dien-16,3-olide(5) 。还利用1H-1H COSY，HMQC，HBMC二维谱首次对dihydroflexibilide(1)所有的1H NMR和13C NMR信号归属作了指定。测定了1 、2和3的细胞毒性。
수차보도유약단지연산호(Sinula ria tenella Li.)적화학성분。종중국남해채집적유약단지연산호중분리득도5개서송희 이첩내지。근거파보수거분석，추도출타문적결구：dihydroflexibilide(1),flxibilide(2)sinulariolide(3),(1R，4R,5R,8S,9S,12S,13S)-9-acetoxy-5,8∶12,13-diepoxy-cembr-15(17 )-en-16,4-olide(4)화(1R,4R,5S 12S,13S)-5-acetoxy -12,13-epoxy-cembr-8E,15(17)-dien-16,3-olide(5) 。환이용1H-1H COSY，HMQC，HBMC이유보수차대dihydroflexibilide(1)소유적1H NMR화13C NMR신호귀속작료지정。측정료1 、2화3적세포독성。
The chemical constituents of marine soft coral Si nularia tenella Li. collected from Hainan Sanya are reported herein for the fir st time. Five cembrenolides ,i. e., dihydroflexibilide，flxibilide ，sinulariol ide，(1R,4R,5R,8S,9S,12S,13S)-9-acetoxy-5,8∶12,13-diepoxy-cembr-15(17 )-en-16,4-olide and (1R,4R,5S,12S,13S)-5-acetoxy-12,13-epoxy-cembr- 8E,15(17)-dien-16,3-olide were isolated and identified by means of spectr oscopic method. Base on the 1H-1H COSY，HMQC and HBMC experiments, all the 1H　NMR and the 13C NMR signals of dihydroflexibil ide were assigned for the first time in this paper.