中西医结合心脑血管病杂志
中西醫結閤心腦血管病雜誌
중서의결합심뇌혈관병잡지
CHINESE JOURNAL OF INTEGRATIVE MEDICINE ON CARDIO-/CEREBROVASCULAR DISEASE
2009年
7期
799-800
,共2页
高脂血症%锌%铜%镁%脂汰清颗粒
高脂血癥%鋅%銅%鎂%脂汰清顆粒
고지혈증%자%동%미%지태청과립
hyperlipidemia%Zn%Cu%Mg%Zhitaiqing granule
目的 探讨脂汰清颗粒对高脂血症兔血清微量元素锌(Zn)、酮(Cu)、镁(Mg)的影响.方法 将1.5 kg～2.0kg普通级雄性新西兰兔随机选取10只作空白对照组,喂普通饲料.余兔按高脂饲料配方1饲喂6周,制成高脂血症模型,再随机分为模型组、脂汰清治疗组、辛伐他汀对照组、山楂精降脂片时照组.从第7周开始,正常组喂全价营养饲料,余组改喂高脂饲料配方2.同时,脂汰清组及两对照组分别给相应溶化药物,空白组和模型组给等量生理盐水.灌胃连续11周后取血清检测微量元素Zn、Cu、Mg.结果 模型组与空白组比较,Zn、Cu、Mg均呈降低趋势(P>0.05).脂汰清治疗组与模型组比较,Zn、Cu、Mg含量轻度上升,且Cu、Mg值超过空白组,但无统计学意义(P>0.05).山楂精降脂片对照组Mg显著升高,与模型组、空白组和辛伐他汀对照组比较,均有统计学意义(P<0.05).结论 脂汰清颗粒对血清Zn、Cu、Mg元素的调节作用不明显.
目的 探討脂汰清顆粒對高脂血癥兔血清微量元素鋅(Zn)、酮(Cu)、鎂(Mg)的影響.方法 將1.5 kg～2.0kg普通級雄性新西蘭兔隨機選取10隻作空白對照組,餵普通飼料.餘兔按高脂飼料配方1飼餵6週,製成高脂血癥模型,再隨機分為模型組、脂汰清治療組、辛伐他汀對照組、山楂精降脂片時照組.從第7週開始,正常組餵全價營養飼料,餘組改餵高脂飼料配方2.同時,脂汰清組及兩對照組分彆給相應溶化藥物,空白組和模型組給等量生理鹽水.灌胃連續11週後取血清檢測微量元素Zn、Cu、Mg.結果 模型組與空白組比較,Zn、Cu、Mg均呈降低趨勢(P>0.05).脂汰清治療組與模型組比較,Zn、Cu、Mg含量輕度上升,且Cu、Mg值超過空白組,但無統計學意義(P>0.05).山楂精降脂片對照組Mg顯著升高,與模型組、空白組和辛伐他汀對照組比較,均有統計學意義(P<0.05).結論 脂汰清顆粒對血清Zn、Cu、Mg元素的調節作用不明顯.
목적 탐토지태청과립대고지혈증토혈청미량원소자(Zn)、동(Cu)、미(Mg)적영향.방법 장1.5 kg～2.0kg보통급웅성신서란토수궤선취10지작공백대조조,위보통사료.여토안고지사료배방1사위6주,제성고지혈증모형,재수궤분위모형조、지태청치료조、신벌타정대조조、산사정강지편시조조.종제7주개시,정상조위전개영양사료,여조개위고지사료배방2.동시,지태청조급량대조조분별급상응용화약물,공백조화모형조급등량생리염수.관위련속11주후취혈청검측미량원소Zn、Cu、Mg.결과 모형조여공백조비교,Zn、Cu、Mg균정강저추세(P>0.05).지태청치료조여모형조비교,Zn、Cu、Mg함량경도상승,차Cu、Mg치초과공백조,단무통계학의의(P>0.05).산사정강지편대조조Mg현저승고,여모형조、공백조화신벌타정대조조비교,균유통계학의의(P<0.05).결론 지태청과립대혈청Zn、Cu、Mg원소적조절작용불명현.
Objective To investigate the effects of Zhitaiqing granule on serum Zn, Cu and Mg in experimental Hyperlipidemic rabbits. Methods Ten New Zealand rabbits were as blank control group fed with normal foods. The rabbits were fed with high fat foods for six weeks, and divided randomly into model group (n= 9), Zhitaiqing granule group(n= 10), simvastatin group (n= 10), and Shanzha-jingzhipian group(n= 10). From the seventh week, rabbits in normal group were fed with the nutrient foods of the full price, while the rest rabbits were fed with high fat foods in another formula. At the same time,dissolvent were fed in Zhitaiqing granule group,simv-astatin group and Shanzhajingzhipian group. Saline were fed by gavage in blank control group and model group. After 11 weeks, the serum Zn,Cu and Mg were detected. Results The levels of serum Zn,Cu and Mg in the model group were lower than that in blank control group, but there was no significantly different(P>0.05). Compared with the model group, the levels of serum Zn,Cu and Mg in Zhitaiqing granule group were increased slightly, but there was no significantly different (P>0.05). The levels of serum Mg in Shanzhajingzhipian group were higher than that in model group,blank control group and simvastatin group(P<0.05). Conclusion Zhitaiqing granule had no significant effects on regulating the serum Zn,Cu and Mg.
