重庆医科大学学报
重慶醫科大學學報
중경의과대학학보
UNIVERSITATIS SCIENTIAE MEDICINAE CHONGQING
2010年
2期
213-216
,共4页
Id_1和Id_3蛋白%非小细胞肺癌%免疫组化
Id_1和Id_3蛋白%非小細胞肺癌%免疫組化
Id_1화Id_3단백%비소세포폐암%면역조화
Id_1 and Id_3 protein%NSCLC%Immunohistochemistry
目的:探索分化抑制因子(Inhibitors of differentiation,Id)Id_1 和 Id_3 在非小细胞肺癌(Non-small cell lung cancer,NSCLC)中的表达及临床意义.方法:采用免疫组化S-P法检测60例NSCLC、8例炎性假瘤、lO例肺结核、12例正常肺组织中Id1和Id3的表达情况.结果:在人NSCLC组织中,Id_1 和 Id_3 均过度表达,与正常肺组织及良性病变组织(结核和炎性假瘤)比较差异具有显著性(P<O.01);在不同年龄、性别及病理类型中表达的差异无统计学意义(P>0.05);在肿瘤有淋巴结转移组中表达的明显高于无淋巴结转移组,统计分析差异具有显著性(P<0.05).结论:Id_1、Id_3蛋白与NSCLC的发生发展及淋巴结转移有关,可能作为NSCLC诊断及判断预后的重要标志物.
目的:探索分化抑製因子(Inhibitors of differentiation,Id)Id_1 和 Id_3 在非小細胞肺癌(Non-small cell lung cancer,NSCLC)中的錶達及臨床意義.方法:採用免疫組化S-P法檢測60例NSCLC、8例炎性假瘤、lO例肺結覈、12例正常肺組織中Id1和Id3的錶達情況.結果:在人NSCLC組織中,Id_1 和 Id_3 均過度錶達,與正常肺組織及良性病變組織(結覈和炎性假瘤)比較差異具有顯著性(P<O.01);在不同年齡、性彆及病理類型中錶達的差異無統計學意義(P>0.05);在腫瘤有淋巴結轉移組中錶達的明顯高于無淋巴結轉移組,統計分析差異具有顯著性(P<0.05).結論:Id_1、Id_3蛋白與NSCLC的髮生髮展及淋巴結轉移有關,可能作為NSCLC診斷及判斷預後的重要標誌物.
목적:탐색분화억제인자(Inhibitors of differentiation,Id)Id_1 화 Id_3 재비소세포폐암(Non-small cell lung cancer,NSCLC)중적표체급림상의의.방법:채용면역조화S-P법검측60례NSCLC、8례염성가류、lO례폐결핵、12례정상폐조직중Id1화Id3적표체정황.결과:재인NSCLC조직중,Id_1 화 Id_3 균과도표체,여정상폐조직급량성병변조직(결핵화염성가류)비교차이구유현저성(P<O.01);재불동년령、성별급병리류형중표체적차이무통계학의의(P>0.05);재종류유림파결전이조중표체적명현고우무림파결전이조,통계분석차이구유현저성(P<0.05).결론:Id_1、Id_3단백여NSCLC적발생발전급림파결전이유관,가능작위NSCLC진단급판단예후적중요표지물.
Objective:To study the expression of Id_1 and Id_3 in human non-small cell lung cancer (NSCLC),and to analyze its potential clinical significance.Methods:Id_1 and Id_3 were detected by immunohistochemical staining technique in paraffine-embedded specimens of 60 NSCIC cases,18 benign disease cases including 10 tuberculosis and 8 inflammatory pseudotumor (IPT),and 12 normal lung cases.and analyzed by the lung cancer clinicopathologic characteristics.Results:There were no Id_1 or Id_3 expression in normal lung tissue,and negative to weak expression of those in benign disease tissues.In contrast,the expression of Id_1 and Id_3 was obviously up-regulated in NSCLC,which was significantly higher than that in benign disease (P<0.01).Furthermore,the over expression of Id_1 and Id_3 was significantly correlated with lymph node metastasis and was not correlated with pathological type,the different age or the different gender of the patients.Conclusion:In NSCLC,Id_1 and Id_3 protein are overexpressed and their expression are positive correlated with lymph node metastasis.It suggested that Id_1 and Id_3 are associated with tumorigenesis,invasion and metastasis in NSCLC.Id_1 and Id_3 might be used as new markers of SCLC for diagnosis and prognosis.
