CAJ | 학술논문

目的超声诊断非酒精性脂肪肝(NAFLD)患病率及分度,分析超声量化分度NAFLD与发生非酒精性脂肪性肝炎(NASH)的关系,分析影响NASH的发病因素.方法门诊健康体检的20～70岁人群进行肝脏B超检查和完整的临床问卷调查及血生化分析,超声发现脂肪肝者,进入临床诊断NAFLD和NASH.结果 1 216例进行肝脏B超检查、血生化分析并完成问卷调查,超声发现脂肪肝365例,检出率30.00%.诊断为NAFLD 279例,占脂肪肝 76.44%.轻度NAFLD142例,占NAFLD的50.90%;中度NAFLD106例,占NAFLD的37.99%;重度NAFLD 31例,占脂肪肝的11.11%.其中116个患者诊断为NASH (占总体的9.53%,占超声诊断NAFLD的41.58%).轻度NAFLD发生NASH45例,占31.69%;中度NAFLD发生NASH 60例,占56.60%;重度NAFLD发生NASH 26例,占83.87%.NASH的发生率与随超声量NAFTD脂肪肝程度增加而增高(P<0.05).超声诊断NAFLD患病率与NASH发生率呈正相关,并随超声检查NAFLD分度增高而增高.Logistic回归分析超声诊断NAFLD中发生NASH与年龄、性别、肥胖、高脂血症、糖尿病的关系,发现年龄对NAFLD发生NASH无统计学意义.而性别、肥胖、高脂血症、糖尿病影响NAFLD中NASH的发生率(P<0.05).结论超声检查NAFLD的分度与NASH的发生呈正相关,NAFLD病变程度越高NASH的发生率亦增高,超声量化诊断NASLF为NASH提供更为准备准确的诊断依据.性别、肥胖、高脂血症、糖尿病是影响NAFLD发生NASH的重要因素.
목적 초성진단비주정성지방간(NAFLD)환병솔급분도,분석초성양화분도NAFLD여발생비주정성지방성간염(NASH)적관계,분석영향NASH적발병인소.방법 문진건강체검적20～70세인군진행간장B초검사화완정적림상문권조사급혈생화분석,초성발현지방간자,진입림상진단NAFLD화NASH.결과 1 216례진행간장B초검사、혈생화분석병완성문권조사,초성발현지방간365례,검출솔30.00%.진단위NAFLD 279례,점지방간 76.44%.경도NAFLD142례,점NAFLD적50.90%;중도NAFLD106례,점NAFLD적37.99%;중도NAFLD 31례,점지방간적11.11%.기중116개환자진단위NASH (점총체적9.53%,점초성진단NAFLD적41.58%).경도NAFLD발생NASH45례,점31.69%;중도NAFLD발생NASH 60례,점56.60%;중도NAFLD발생NASH 26례,점83.87%.NASH적발생솔여수초성량NAFTD지방간정도증가이증고(P<0.05).초성진단NAFLD환병솔여NASH발생솔정정상관,병수초성검사NAFLD분도증고이증고.Logistic회귀분석초성진단NAFLD중발생NASH여년령、성별、비반、고지혈증、당뇨병적관계,발현년령대NAFLD발생NASH무통계학의의.이성별、비반、고지혈증、당뇨병영향NAFLD중NASH적발생솔(P<0.05).결론 초성검사NAFLD적분도여NASH적발생정정상관,NAFLD병변정도월고NASH적발생솔역증고,초성양화진단NASLF위NASH제공경위준비준학적진단의거.성별、비반、고지혈증、당뇨병시영향NAFLD발생NASH적중요인소.