CAJ | 학술논문

目的探讨乳腺癌超声造影增强特征与诺丁汉预后指数(Nottingham prognostic index,NPI)的相关性.方法回顾分析91例经手术病理证实的乳腺癌的超声影像特点及微血管成像表现,按NPI的评分分为3组.结果 NPI评分3组为:＜3.4分的19例,3.4 ～5.4的52例,＞5.4的21例.随着NPI增加,病灶内不均匀性增强、灌注缺损、病灶边缘增强高于中心区增强及增强边界欠清或不清的比例增加,3组间差异有统计学意义(P＜0.05),但增强顺序的类别无统计学意义(P＞0.05).3组病灶均以“高增强”为主,增强强度3组差异均无统计学意义(P＞0.05).随着NPI增加,病灶以“早增强”、“慢消退”表现的比例逐渐增多,3组间差异均有统计学意义(P＜0.05).3组乳腺癌病灶内部微血管构筑模式与NPI评分之间无显著相关(P＞0.05)；病灶内部血管增粗、扭曲及病灶周边微血管呈“毛刺状”、扭曲、增粗随NPI评分增高而出现几率增加,3组间差异均有统计学意义(P＜0.05).结论乳腺癌超声造影增强特征与NPI评分有一定的相关性,对判断乳腺癌预后有提示作用.
목적 탐토유선암초성조영증강특정여낙정한예후지수(Nottingham prognostic index,NPI)적상관성.방법 회고분석91례경수술병리증실적유선암적초성영상특점급미혈관성상표현,안NPI적평분분위3조.결과 NPI평분3조위:＜3.4분적19례,3.4 ～5.4적52례,＞5.4적21례.수착NPI증가,병조내불균균성증강、관주결손、병조변연증강고우중심구증강급증강변계흠청혹불청적비례증가,3조간차이유통계학의의(P＜0.05),단증강순서적유별무통계학의의(P＞0.05).3조병조균이“고증강”위주,증강강도3조차이균무통계학의의(P＞0.05).수착NPI증가,병조이“조증강”、“만소퇴”표현적비례축점증다,3조간차이균유통계학의의(P＜0.05).3조유선암병조내부미혈관구축모식여NPI평분지간무현저상관(P＞0.05)；병조내부혈관증조、뉴곡급병조주변미혈관정“모자상”、뉴곡、증조수NPI평분증고이출현궤솔증가,3조간차이균유통계학의의(P＜0.05).결론 유선암초성조영증강특정여NPI평분유일정적상관성,대판단유선암예후유제시작용.
Objective To study the correlation between contrast-enhanced ultrasound (CEUS) features and Nottingham prognostic index (NPI) in patients with breast carcinoma. Methods The ultrasound features and microvascular imaging manifestation of 91 breast carcinomas confirmed by pathology were retrospectively analyzed.NPI was typically stratified into 3 major groups:NPI ＜ 3.4 ( n =19 ), NPI:3.4-5.4 ( n =52 ) and NPI ＞5.4(n =21 ). Results With the increase of NPI, the rate of heterogeneous enhancement, perfusion defects, edge enhancement higher than center enhancement, and unclear border increased.The difference among the 3 groups had statistical significance (P ＜ 0.05 ).There was no significant difference in enhancement order among the 3 groups ( P ＞ 0.05 ).The lesions of the 3 groups were mainly “high enhancement” and there was no significant difference among the 3 groups ( P ＞ 0.05 ).With the increase of NPI, the rate of early enhancement and late regression increased.The difference among the 3 groups had statistical significance ( P ＜ 0.05 ).With the increase of NPI, the rate of enlarged and twisted vessels as well as peripheral vessel burr increased.There was significant difference among the 3 groups ( P ＜ 0.05 ).Conclusion CEUS festures and microvescular architecture pattern of breast carcinoma are related to NPI, which is useful in predicating the prognosis of breast carcinoma.