CAJ | 학술논문

目的观察血浆同型半胱氨酸(Hcy)水平与中青年脑梗死的关系,探讨Hcy在中青年脑梗死发生、发展中的临床意义.方法应用循环酶法测定132例中青年脑梗死患者(观察组)及86例健康对照者的血浆Hcy水平,并进行比较.结果观察组的血浆Hcy水平高于对照组[(24.32±5.68)、(12.58±3.53)μmol/L],差异有统计学意义(t=17.26,P＜0.01).血浆Hcy水平越高,急性期脑梗死的病灶越大,两者呈直线正相关关系(r =0.696,P＜0.01).结论高同型半胱氨酸血症(HH)是中青年脑梗死的危险因素,血浆Hcy水平越高,急性期脑梗死的病灶越大；血浆Hcy水平能反映脑梗死灶的大小及病情程度；对有脑血管病倾向的中青年,血浆Hcy检查应作为常规检查或作为病情监测和预后判断的重要指标.
목적 관찰혈장동형반광안산(Hcy)수평여중청년뇌경사적관계,탐토Hcy재중청년뇌경사발생、발전중적림상의의.방법 응용순배매법측정132례중청년뇌경사환자(관찰조)급86례건강대조자적혈장Hcy수평,병진행비교.결과 관찰조적혈장Hcy수평고우대조조[(24.32±5.68)、(12.58±3.53)μmol/L],차이유통계학의의(t=17.26,P＜0.01).혈장Hcy수평월고,급성기뇌경사적병조월대,량자정직선정상관관계(r =0.696,P＜0.01).결론 고동형반광안산혈증(HH)시중청년뇌경사적위험인소,혈장Hcy수평월고,급성기뇌경사적병조월대；혈장Hcy수평능반영뇌경사조적대소급병정정도；대유뇌혈관병경향적중청년,혈장Hcy검사응작위상규검사혹작위병정감측화예후판단적중요지표.
Objective To observe the relationship between plasma level of homocysteine(HCY) and ischemic stroke in young and middle-aged adults,explore the clinical signficance concerning the occurrence and development of ischemic stroke in young and middle-aged adults.Methods The plasma homocysteine level of 132 young and middle-aged adults patients with ischemic and 86 control peoples were measured by means of enzymatic cycling assay.Results The plasma homocysteine level in ischemic stroke was higher than that in control group( P ＜ 0.01 ).The higher the plasma homocysteine level,the larger infarcted focus in acute ischemic stroke group of young and middleaged adults.The plasma homocysteine level and the infarcted focus was positively linearly correlated.Conclusion Hyperhomocysteinemia is a risk factor of ischemic stroke among young and middle-aged adults.The higher the plasma homocysteine level,the larger infarcted focus in acute ischemic stroke group.The plasma homocysteine level can reflect the size of the infarcted focus and the degree of disease,and the plasma homocysteine level should serve as a kind of regular examination or as an index intervention can be taken,all of which are great importance to prevent ischemic stroke and reduce its morbilily.