中国医药
中國醫藥
중국의약
CHINA MEDICINE
2009年
9期
659-660
,共2页
急性冠状动脉综合征%心绞痛%C反应蛋白%心肌梗死
急性冠狀動脈綜閤徵%心絞痛%C反應蛋白%心肌梗死
급성관상동맥종합정%심교통%C반응단백%심기경사
Acute coronary syndrome%Angina pectoris%C-reactive protein%Myocardial infarction
目的 通过观察炎症反应标志物 C 反应蛋白情况探讨炎症与急性冠状动脉综合征、稳定型心绞痛的关系,及其在急性心肌梗死中发生心脏事件的特点.方法 96 例受试者共分为3组:急性心肌梗死组28例,不稳定型心绞痛组35例,稳定型心绞痛组 33 例,另选对照组 28 例.采用免疫比浊法测定4组患者C反应蛋白含量.结果 急性心肌梗死组和不稳定型心绞痛组C反应蛋白明显高于稳定型心绞痛组和对照组[分别为(113.03±61.23)、(25.26±18.13)、(5.13±3.86)、(3.26±1.98)ms/L].急性心肌梗死组C反应蛋白显著高于不稳定型心绞痛组、稳定型心绞痛组、对照组.不稳定型心绞痛组与稳定型心绞痛组及对照组相比,C反应蛋白增高,差异均有统计学意义(P<0.05).稳定型心绞痛组与对照组相比,C反应蛋白升高程度的差异无统计学意义.急性心肌梗死组中C反应蛋白在发病后48 h达到峰值.急性心肌梗死组中发生心脏事件患者的C反应蛋白水平[(69.23±26.22)ms/L]明显高于其中未发生心脏事件的患者[(95.34±43.45)ms/L].结论 发生急性冠状动脉综合征时c反应蛋白显著升高,表明急性冠状动脉综合征过程中存在炎症反应,并在一定程度上反映心肌损伤及坏死的严重程度.急性心肌梗死中c反应蛋白显著升高,可较好地预测急性心肌梗死心脏事件的发生.
目的 通過觀察炎癥反應標誌物 C 反應蛋白情況探討炎癥與急性冠狀動脈綜閤徵、穩定型心絞痛的關繫,及其在急性心肌梗死中髮生心髒事件的特點.方法 96 例受試者共分為3組:急性心肌梗死組28例,不穩定型心絞痛組35例,穩定型心絞痛組 33 例,另選對照組 28 例.採用免疫比濁法測定4組患者C反應蛋白含量.結果 急性心肌梗死組和不穩定型心絞痛組C反應蛋白明顯高于穩定型心絞痛組和對照組[分彆為(113.03±61.23)、(25.26±18.13)、(5.13±3.86)、(3.26±1.98)ms/L].急性心肌梗死組C反應蛋白顯著高于不穩定型心絞痛組、穩定型心絞痛組、對照組.不穩定型心絞痛組與穩定型心絞痛組及對照組相比,C反應蛋白增高,差異均有統計學意義(P<0.05).穩定型心絞痛組與對照組相比,C反應蛋白升高程度的差異無統計學意義.急性心肌梗死組中C反應蛋白在髮病後48 h達到峰值.急性心肌梗死組中髮生心髒事件患者的C反應蛋白水平[(69.23±26.22)ms/L]明顯高于其中未髮生心髒事件的患者[(95.34±43.45)ms/L].結論 髮生急性冠狀動脈綜閤徵時c反應蛋白顯著升高,錶明急性冠狀動脈綜閤徵過程中存在炎癥反應,併在一定程度上反映心肌損傷及壞死的嚴重程度.急性心肌梗死中c反應蛋白顯著升高,可較好地預測急性心肌梗死心髒事件的髮生.
목적 통과관찰염증반응표지물 C 반응단백정황탐토염증여급성관상동맥종합정、은정형심교통적관계,급기재급성심기경사중발생심장사건적특점.방법 96 례수시자공분위3조:급성심기경사조28례,불은정형심교통조35례,은정형심교통조 33 례,령선대조조 28 례.채용면역비탁법측정4조환자C반응단백함량.결과 급성심기경사조화불은정형심교통조C반응단백명현고우은정형심교통조화대조조[분별위(113.03±61.23)、(25.26±18.13)、(5.13±3.86)、(3.26±1.98)ms/L].급성심기경사조C반응단백현저고우불은정형심교통조、은정형심교통조、대조조.불은정형심교통조여은정형심교통조급대조조상비,C반응단백증고,차이균유통계학의의(P<0.05).은정형심교통조여대조조상비,C반응단백승고정도적차이무통계학의의.급성심기경사조중C반응단백재발병후48 h체도봉치.급성심기경사조중발생심장사건환자적C반응단백수평[(69.23±26.22)ms/L]명현고우기중미발생심장사건적환자[(95.34±43.45)ms/L].결론 발생급성관상동맥종합정시c반응단백현저승고,표명급성관상동맥종합정과정중존재염증반응,병재일정정도상반영심기손상급배사적엄중정도.급성심기경사중c반응단백현저승고,가교호지예측급성심기경사심장사건적발생.
Objective To explore the correlation between inflammation and acute coronary syndrome (ACS), stable angina pectoris(SAP) and to investigate characteristics of cardiovascular events in acute myocardial infarction (AMI)via detecting C-reactive protein(CRP). Methods One hundred and twenty-four cases were divid-ed into AMI group (28 patients) and UAP group (35 patients). There were 33 cases in SAP group and 28 cases in normal control group. CRP concentration (mg/L) was determined by immune transmission turbidity. Results CRP significantly increased in AMI and UAP group compared with normal control group. CRP was higher in AMI group than in UAP group, SAP group and control group. CRP in UAP group was higher than in SAP group and normal control group. Compared with control group, CRP in SAP group did not significantly increase. CRP peak occurred at 48 hours after AMI. CRP in AMI (cardiovascular events) subgroup was higher than in AMI (no cardiovascular) subgroup. Conclusion Significant elevation of CRP suggests that inflammation occurs in ACS courses and reflects certain degree of myocardial injury and necroses. Significant increase of CRP can predict cardiovascular events in AMI.
