CAJ | 학술논문

目的应用心肌造影超声心动图(MCE)结合速度向量成像(VVI)技术研究糖尿病(DM)大鼠左室心肌微循环障碍与心肌收缩功能损伤之间的相关关系.方法雄性SD大鼠23只,腹腔注射链脲菌素复制DM模型,另23只体质量匹配的雄性SD大鼠腹腔注射等量生理盐水作为对照.分别在静息状态和潘生丁负荷后,对两组大鼠(12周)乳头肌水平左室短轴行MCE和VVI检查,分别测定心肌血流量(MBF)、心肌血流储备(MFR)、收缩期最大圆周应变率(SRc)及其储备,分析MBF/MFR与SRc/SRc储备之间是否存在相关关系.结果 DM组大鼠的SRc、SRc储备、MBF及MFR均较对照组显著减低.DM组大鼠SRc与MBF之间没有明显相关性,而SR.储备与MFR之间呈现显著的负相关.结论静息状态下,心肌血流量的降低并不是圆周应变率降低的主要决定因素,而潘生丁负荷后,心肌血流储备的降低可能是心肌圆周应变率储备降低的主要决定因素.
목적 응용심기조영초성심동도(MCE)결합속도향량성상(VVI)기술연구당뇨병(DM)대서좌실심기미순배장애여심기수축공능손상지간적상관관계.방법 웅성SD대서23지,복강주사련뇨균소복제DM모형,령23지체질량필배적웅성SD대서복강주사등량생리염수작위대조.분별재정식상태화반생정부하후,대량조대서(12주)유두기수평좌실단축행MCE화VVI검사,분별측정심기혈류량(MBF)、심기혈류저비(MFR)、수축기최대원주응변솔(SRc)급기저비,분석MBF/MFR여SRc/SRc저비지간시부존재상관관계.결과 DM조대서적SRc、SRc저비、MBF급MFR균교대조조현저감저.DM조대서SRc여MBF지간몰유명현상관성,이SR.저비여MFR지간정현현저적부상관.결론 정식상태하,심기혈류량적강저병불시원주응변솔강저적주요결정인소,이반생정부하후,심기혈류저비적강저가능시심기원주응변솔저비강저적주요결정인소.
Objective To investigate whether myocardial dysfunction and perfusion impairment had happened in diabetes mellitus(DM)rats,and to assess the relationship between them by using myocardial contrast echocardiography(MCE)and velocity vector imaging(VVI).Methods MCE and VVI were performed from the short-axis views of the mid-left ventricular level both at rest and after dipyridamole stress in control rats and DM rafs(12 weeks after induction with streptozotocin).MCE-derived myocardial blood flow(MBF)and myocardial flow reserve(MFR)and VVI-derived circumferential strain rate(SRc)and SRc reserve were obtained.Results SRc(absolute value)and MBF in the DM group were significantly lower than those in the control group at rest(P =0.03 for SRc and P =0.005 for MBF).SRc reserve and MFR in the DM group were significantly lower than those in the control group after dipyridamole stress (P =0.000 for SRc reserve and P =0.014 for MFR).There was no significant correlation between SRc and MBF at rest in the DM group(r =0.189,P =0.453).However,significant negative correlation existed between SRc reserve and MFR(r =-0.658,P =0.003).Conclusions Both myocardial systolic function and perfusion are impaired in DM rats.The decrease of MBF might not be the predominant determinant of myocardial systolic dysfunction at rest.However,the impairment of MFR could be an important contributor to the decrease of myocardial contractile reserve.