CAJ | 학술논문

目的探讨老年高血压患者血压晨峰现象对颈动脉粥样硬化(CAS)的影响.方法以106例老年原发性高血压患者为研究对象,根据24 h动态血压监测结果将患者分为晨峰组(n=58)和非晨峰组(n=48),通过颈动脉超声测量颈总动脉内膜中层厚度(CCA-IMT),比较两组CCA-IMT及颈动脉斑块的差别.结果晨峰组CCA-IMT显著大于非晨峰组[(1.27±0.12)mm与(0.92±0.33)mm,P＜0.05)];晨峰组Ⅱ级及Ⅱ级以上严重颈动脉斑块发生率显著高于非晨峰组(72.15%与54.21%,P＜0.01);CCA-IMT与年龄(r=0.288,P＜0.001)、24 h平均收缩压(r=0.368,P＜0.001)、晨峰血压(r=0.768,P＜0.001)呈正相关.结论老年原发性高血压晨峰现象是颈动脉粥样硬化及斑块形成的危险因素之一.
목적 탐토노년고혈압환자혈압신봉현상대경동맥죽양경화(CAS)적영향.방법 이106례노년원발성고혈압환자위연구대상,근거24 h동태혈압감측결과장환자분위신봉조(n=58)화비신봉조(n=48),통과경동맥초성측량경총동맥내막중층후도(CCA-IMT),비교량조CCA-IMT급경동맥반괴적차별.결과 신봉조CCA-IMT현저대우비신봉조[(1.27±0.12)mm여(0.92±0.33)mm,P＜0.05)];신봉조Ⅱ급급Ⅱ급이상엄중경동맥반괴발생솔현저고우비신봉조(72.15%여54.21%,P＜0.01);CCA-IMT여년령(r=0.288,P＜0.001)、24 h평균수축압(r=0.368,P＜0.001)、신봉혈압(r=0.768,P＜0.001)정정상관.결론 노년원발성고혈압신봉현상시경동맥죽양경화급반괴형성적위험인소지일.
Objective To investigate the association between morniing blood pressure surge (MBPS) and carotid atherosclerosis in elder patients with essential hypertension. Methods According to the results of24h ambulatory blood pressure monitoring, 106 patients were classified as the morning BP surge group (MBPS group,n = 58) ,and nonsurge group (NMBPS group, n = 48). Patients underwent carotid ultrasound and the intima-medial thickness (CCA-IMT) and plaques were examined. Results The CCA-IMT of the MBPS group was significantly thicker than that the NMBPS group[(1.27 ± 0. 12)mm vs (0.92 ± 0.33 )mm], P ＜ 0. 05 ) ;②Compared with the NMBPS group,the severity of carotid arteries plaque of the MBPS group was significantly higher (72. 15% vs 54.21% ), ( P ＜0. 01 ) ;③Pearson relation analysis showed CCA-IMT level positively correlated with age (r = 0.288, P ＜ 0.001 ) ,the average of 24h SBP ( r = 0. 768 ,P ＜ 0. 001 ), and MBPS ( r = 0. 768, P ＜ 0.001 ). Conclusion The study showed that MBPS was closely related with carotid atherosclerosis in elder patients with essential hypertension and was an important risk factor in the process of atheresclerosis.