中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2012年
6期
469-471
,共3页
陈安%王东之%徐更华%王俊%陶晓剑%王益波%杨晓翠%宋洁
陳安%王東之%徐更華%王俊%陶曉劍%王益波%楊曉翠%宋潔
진안%왕동지%서경화%왕준%도효검%왕익파%양효취%송길
高血压%高脂血症%动脉粥样硬化
高血壓%高脂血癥%動脈粥樣硬化
고혈압%고지혈증%동맥죽양경화
Hypertension%Hyperlipidemia%Atherosclerosis
目的 探讨氨氯地平阿托伐他汀钙(多达一)对老年人高血压并存高脂血症患者动脉粥样硬化水平的影响.方法 选取我院收治的108例高血压并存高脂血症患者,并将其随机均分为对照组及观察组,每组54例.其中对照组采用利尿剂、血管紧张素转换酶抑制剂、钙拮抗剂及β受体阻滞剂等常规降压方法治疗；观察组在其基础上加用多达一,两组同时服用,6个月为1疗程.对比观察两组治疗后血脂水平及颈动脉超声检测结果.结果 观察组治疗后较对照组总胆固醇(TC)[(4.23±0.79)mmol/L比(5.32±1.23) mmol/L]、三酰甘油(TG)[(1.53±0.35) mmol/L比(5.32±1.23) mmol/L]、低密度脂蛋白胆固醇(LDL-C)[(3.19±0.59)mmol/L比(4.07±0.79) mmol/L]水平明显下降,高密度脂蛋白胆固醇(HDL-C)[(1.53±0.95)mmol/L比(1.32±0.83)mmol/L]明显升高,差异有统计学意义(P＜0.05).观察组治疗后颈动脉超声检查冠状动脉钙化积分(LN)[(1.61±0.76)分比(2.24±0.89)分]和颈动脉内膜中层(IMT)[(0.76±0.22)mm比(0.98±0.28)mm]水平较对照组治疗后明显下降(P＜0.05).结论 多达一能够有效降低血脂,缓解动脉粥样硬化,适用于高血压合并高脂血症患者.
目的 探討氨氯地平阿託伐他汀鈣(多達一)對老年人高血壓併存高脂血癥患者動脈粥樣硬化水平的影響.方法 選取我院收治的108例高血壓併存高脂血癥患者,併將其隨機均分為對照組及觀察組,每組54例.其中對照組採用利尿劑、血管緊張素轉換酶抑製劑、鈣拮抗劑及β受體阻滯劑等常規降壓方法治療；觀察組在其基礎上加用多達一,兩組同時服用,6箇月為1療程.對比觀察兩組治療後血脂水平及頸動脈超聲檢測結果.結果 觀察組治療後較對照組總膽固醇(TC)[(4.23±0.79)mmol/L比(5.32±1.23) mmol/L]、三酰甘油(TG)[(1.53±0.35) mmol/L比(5.32±1.23) mmol/L]、低密度脂蛋白膽固醇(LDL-C)[(3.19±0.59)mmol/L比(4.07±0.79) mmol/L]水平明顯下降,高密度脂蛋白膽固醇(HDL-C)[(1.53±0.95)mmol/L比(1.32±0.83)mmol/L]明顯升高,差異有統計學意義(P＜0.05).觀察組治療後頸動脈超聲檢查冠狀動脈鈣化積分(LN)[(1.61±0.76)分比(2.24±0.89)分]和頸動脈內膜中層(IMT)[(0.76±0.22)mm比(0.98±0.28)mm]水平較對照組治療後明顯下降(P＜0.05).結論 多達一能夠有效降低血脂,緩解動脈粥樣硬化,適用于高血壓閤併高脂血癥患者.
목적 탐토안록지평아탁벌타정개(다체일)대노년인고혈압병존고지혈증환자동맥죽양경화수평적영향.방법 선취아원수치적108례고혈압병존고지혈증환자,병장기수궤균분위대조조급관찰조,매조54례.기중대조조채용이뇨제、혈관긴장소전환매억제제、개길항제급β수체조체제등상규강압방법치료；관찰조재기기출상가용다체일,량조동시복용,6개월위1료정.대비관찰량조치료후혈지수평급경동맥초성검측결과.결과 관찰조치료후교대조조총담고순(TC)[(4.23±0.79)mmol/L비(5.32±1.23) mmol/L]、삼선감유(TG)[(1.53±0.35) mmol/L비(5.32±1.23) mmol/L]、저밀도지단백담고순(LDL-C)[(3.19±0.59)mmol/L비(4.07±0.79) mmol/L]수평명현하강,고밀도지단백담고순(HDL-C)[(1.53±0.95)mmol/L비(1.32±0.83)mmol/L]명현승고,차이유통계학의의(P＜0.05).관찰조치료후경동맥초성검사관상동맥개화적분(LN)[(1.61±0.76)분비(2.24±0.89)분]화경동맥내막중층(IMT)[(0.76±0.22)mm비(0.98±0.28)mm]수평교대조조치료후명현하강(P＜0.05).결론 다체일능구유효강저혈지,완해동맥죽양경화,괄용우고혈압합병고지혈증환자.
Objective To investigate influence of amlodipine /atorvastatin on atherosclerosis in the elderly with hypertension and hyperlipidemia.Methods Totally 108 cases with hypertension and hyperlipidemia in our hospital were randomly divided into control group and observation group (n =54 each).The control group received conventional antihypertensive treatment such as diuretics,angiotensin-converting enzyme inhibitors,calcium antagonists; the observation group received amlodipine and atorvastatin combination tablet as add-on therapy to the above drugs for 6 months.The blood lipid level and carotid artery ultrasound detection results were observed and compared between the two groups after treatment.Results The levels of TC[(4.23 ± 0.79)mmol/L vs.( 5.32 ±1.23)mmol/L],TG[(1.53±0.35) mmol/L vs.(5.32± 1.23) mmol/L],LDL-C [(3.19 ± 0.59)mmol/L vs.(4.07±0.79)mmo1/L]were decreased,while HDL-C [(1.53±0.95)mmol/L vs.(1.32±0.83)mmol/L]were increased in observation group after treatment as compared to control group (all P ＜0.05).After carotid artery ultrasonography,the LN[( 1.61± 0.76) scores vs.( 2.24 ± 0.89) scores ] and IMT [(0.76 ± 0.22)mm vs.(0.98 ± 0.28)mm] levels were lower in observation group after treatment than in control group (P＜0.05).Conclusions Amlodipine/atorvastatin combination can reduce blood lipids and alleviate atherosclerosis.It is suitable for elderly patients with hypertension and hyperlipidemia.
