CAJ | 학술논문

目的探讨钡铁氧化合物(BaFe12O19)微粒作为一种新开发的新型血管内栓塞材料的生物相容性.方法对BaFe12O19微粒进行系列生物相容性实验,包括Ames致突变实验、细胞毒性实验、全身急性和亚急性毒性实验、溶血实验、出血和凝血时间测定、凝血功能实验等.结果 BaFe12O19微粒无致突变性,无毒性,对出血和凝血时间无显著性影响,不引起溶血和凝血功能的改变.结论 BaFe12O19微粒具有良好的生物相容性.
목적 탐토패철양화합물(BaFe12O19)미립작위일충신개발적신형혈관내전새재료적생물상용성.방법 대BaFe12O19미립진행계렬생물상용성실험,포괄Ames치돌변실험、세포독성실험、전신급성화아급성독성실험、용혈실험、출혈화응혈시간측정、응혈공능실험등.결과 BaFe12O19미립무치돌변성,무독성,대출혈화응혈시간무현저성영향,불인기용혈화응혈공능적개변.결론 BaFe12O19미립구유량호적생물상용성.
Objective To investigate the biocompatibility of BaFe12O19 particles as supposed to be a new kind of endovascular embolization material. Methods The biocompatibility of BaFe12O19 particles was evaluated in vitro, including Ames test, cell toxicity test, acute and subacutc systemic toxicity test, hemolysis test,hemopexis test and bleeding time and clotting time test. Results The material had no toxicity, no stimulation and mutation,and it did not cause hemolysis and hemopexis, and had no influence on bleeding time and clotting time. Conclusion The biocompatibility of BaFe12O19 particles was up to standard.