CAJ | 학술논문

为探讨血清β-Ⅰ型胶原羧端肽(β-CTX)、血骨钙素(M-MID)和尿Ⅰ型胶原羧端肽/肌酐(CTX/CR)在监测肺痛骨转移中的意义,收集2007年5月至2008年5月期间住院的肺癌骨转移患者24例(转移组),无骨转移肺癌患者26例(无转移组)及正常对照27例(正常对照组),全部检测血清β-CTX、血M-MID及尿CTX/CR比值.结果发现肺癌骨转移组的血β-CTX和尿CTX/CR明显高于无骨转移及正常对照组,检测这两项指标可以为临床判断肺癌骨转移提供参考.
위탐토혈청β-Ⅰ형효원최단태(β-CTX)、혈골개소(M-MID)화뇨Ⅰ형효원최단태/기항(CTX/CR)재감측폐통골전이중적의의,수집2007년5월지2008년5월기간주원적폐암골전이환자24례(전이조),무골전이폐암환자26례(무전이조)급정상대조27례(정상대조조),전부검측혈청β-CTX、혈M-MID급뇨CTX/CR비치.결과 발현폐암골전이조적혈β-CTX화뇨CTX/CR명현고우무골전이급정상대조조,검측저량항지표가이위림상판단폐암골전이제공삼고.
The study included 24 patients of lung cancer with bone metastasis, 26 patients of lung cancer without bone metastasis and 27 healthy controls. The serum levels of β-crosslaps of type Ⅰ collagen (β-CTX), M-MID and urinary β-CTX/creatinine (CTX/CR) were measured by ELISA. Results showed that the serum levels of β-CTX and urinary CTX/CR in lung cancer patients with bone metastasis were significantly higher than those without bone metastasis (P ＜ 0. 01 ). The findings suggest that the measurement of serum β-CTX and urinary CTX/CR may indicate bone metastasis in lung cancer.