CAJ | 학술논문

目的利用磁源性影像技术以及表情事件相关识别实验范式探讨抑郁症患者识别负性动态表情的神经网络磁源性影像动态变化的特点.方法利用脑磁图检测12例抑郁症患者(患者组)及12名年龄、性别、受教育年限近似匹配的健康对照者(对照组)识别负性动态表情视频时的脑部反应.设P＜0.01时,差异均具有统计学意义.结果与对照组相比,患者组识别负性面部表情时,活动异常主要出现在双侧钩回、双侧颞上回、右额中回、右杏仁核、右颞回下、左梭状回、左枕下回、右海马旁回、左枕舌回、双侧楔前叶、左楔叶等脑区,这些脑区组成的神经网络在识别负性动态表情过程有相应脑区激活异常.结论抑郁症患者识别负性表情的功能网络的脑磁源性影像动态变化特点与正常人比较差异有统计学意义.
목적 이용자원성영상기술이급표정사건상관식별실험범식탐토억욱증환자식별부성동태표정적신경망락자원성영상동태변화적특점.방법 이용뇌자도검측12례억욱증환자(환자조)급12명년령、성별、수교육년한근사필배적건강대조자(대조조)식별부성동태표정시빈시적뇌부반응.설P＜0.01시,차이균구유통계학의의.결과 여대조조상비,환자조식별부성면부표정시,활동이상주요출현재쌍측구회、쌍측섭상회、우액중회、우행인핵、우섭회하、좌사상회、좌침하회、우해마방회、좌침설회、쌍측설전협、좌설협등뇌구,저사뇌구조성적신경망락재식별부성동태표정과정유상응뇌구격활이상.결론 억욱증환자식별부성표정적공능망락적뇌자원성영상동태변화특점여정상인비교차이유통계학의의.
Objective To explore the features of functional networks about recognizing dynamically negative expression using magnetoencephalography (MEG) and the paradigm of expressional experiment,and to examine its neurological basis. Methods Twelve depressed patients and 12 age- and educationmatched healthy controls participated to recognize the dynamically negative expression during MEG scanning. Results Compared with healthy controls, the abnormally activities regions in depressed patients during different time periods were separately as follow: the bilateral uncus gyrus, bilateral superior temporal gyrus, right middle frontal gyrus, right amygdale, right temporal sub-gyrus, left angular gyrus, left caudate nucleus head, left inferior occipital gyrus, right parahippocampal gyrus, left fusiform gyrus, bilateral precuneus, left anterior lobe culmen, and left cuneus ( P＜0.01, uncorrected). Conclusion Abnormal brain activity is distributed extensively in depressed patients during recognizing dynamically negative expression, which may prompt the features of functional networks about recognizing dynamically negative expression.