CAJ | 학술논문

树突状细胞(DC)在T细胞介导的免疫反应中起核心作用,可在体内外诱导强烈的抗肿瘤免疫反应.DC作为恶性肿瘤免疫治疗因子被广泛的研究.如今,开发了多种基于DC的抗肿瘤免疫治疗.然而肿瘤也会影响宿主的造血功能以及导致大量未成熟和免疫耐受的DC产生,这些直接抑制免疫反应.了解肿瘤相关DC的免疫抑制作用机制,可提高对肿瘤免疫逃逸的认识.
수돌상세포(DC)재T세포개도적면역반응중기핵심작용,가재체내외유도강렬적항종류면역반응.DC작위악성종류면역치료인자피엄범적연구.여금,개발료다충기우DC적항종류면역치료.연이종류야회영향숙주적조혈공능이급도치대량미성숙화면역내수적DC산생,저사직접억제면역반응.료해종류상관DC적면역억제작용궤제,가제고대종류면역도일적인식.
Dendritic cells (DCs) play a pivotal role in T cell-mediated immunity. These cells have been shown to induce strong antitumor immune responses in vitro and in vivo. DCs have been widely used as immunotherapeutic agents for the treatment of disseminated malignancies. At present, a number of DC-based tumor immunotherapies have been developed. However, tumors also alter host hematopoiesis and induce large numbers of immature and immunotolerant DCs. Evidence showed that these cells could directly inhibit immune responses against tumors. To here we will discuss the mechanism of immune suppression of tumor associated DCs. Improve the understanding on tumor immune escape.