CAJ | 학술논문

背景研究表明脊髓胶质细胞(星形胶质细胞和小胶质细胞)在各种病理性疼痛模型中活化,并且活化的胶质细胞在各种病理性疼痛的发生和发展中具有重要作用.目的探讨脊髓胶质细胞在病理性疼痛调节中的作用.内容从脊髓胶质细胞活化参与病理性疼痛调节的生理基础,脊髓胶质细胞活化及其检测,脊髓胶质细胞活化与病理性疼痛和脊髓胶质细胞参与病理性疼痛的调节机制等几方面就与此有关的研究进展进行了综述.趋向胶质细胞将继续引起疼痛研究者的关注,因为它为临床病理性疼痛的治疗提供了新的靶点.
배경 연구표명척수효질세포(성형효질세포화소효질세포)재각충병이성동통모형중활화,병차활화적효질세포재각충병이성동통적발생화발전중구유중요작용.목적 탐토척수효질세포재병이성동통조절중적작용.내용 종척수효질세포활화삼여병이성동통조절적생리기출,척수효질세포활화급기검측,척수효질세포활화여병이성동통화척수효질세포삼여병이성동통적조절궤제등궤방면취여차유관적연구진전진행료종술.추향 효질세포장계속인기동통연구자적관주,인위타위림상병이성동통적치료제공료신적파점.
Background Considerable studies have demonstrated that activation of spinal cord glial cells (astrocytes and microglia) is a common phenomenon in various pathological pain models, and the activated glial cells play an important role in the development and maintenance of pathological pain. Purpose To explore the role of spinal cord glia in pathological pain modulation. Content This article reviews the research advances in the role of spinal cord glia. It focuses on the several aspects of spinal cord glia-the physiological basis of glia contributing to pathological pain, glial activation and its detection, activation of glia and pathological pain, and glial modulation of pain. Trend Glial cells have been drawing the attention of pain researchers because targeting spinal cord glia is a new view of clinical pain therapies.