CAJ | 학술논문

肺动脉高压是慢性阻塞性肺疾病的一个重要合并症.慢性阻塞性肺疾病相关的肺动脉高压多为轻到中度且进展缓慢,香烟烟雾、炎症产物引起内皮损害,造成内皮功能失调；慢性低氧引起肺血管收缩；肺血管重塑导致管腔变小；血管膨胀性降低,阻力增加；重度肺气肿时肺-毛细血管的丧失等均与慢性阻塞性肺疾病时的肺动脉高压相关.
폐동맥고압시만성조새성폐질병적일개중요합병증.만성조새성폐질병상관적폐동맥고압다위경도중도차진전완만,향연연무、염증산물인기내피손해,조성내피공능실조；만성저양인기폐혈관수축；폐혈관중소도치관강변소；혈관팽창성강저,조력증가；중도폐기종시폐-모세혈관적상실등균여만성조새성폐질병시적폐동맥고압상관.
Pulmonary hypertension (PH)is a common complication of chronic obstructive pulmonary disease(COPD).In COPD,PH tends to be of moderate severity and progresses slowly. Its presence is associated with shorter survival and worse clinical evolution.The combined effects appear to contribute to the development of PH associated with COPD.Toxic effects of cigarette smoke components or inflammation products may damage endothelial cells and produce endothelial dysfunction.Hypoxia may induce vasoconstriction.Pulmonary vascular remodeling leads to reduction of arterial lumen and distensibility of the pulmonary vessels,which increase pulmonary vascular resistance.Severe emphysema leads to reduction in the total number of pulmonary vessels.All these contribute to the development of PH in COPD.