CAJ | 학술논문

目的　进一步揭示海洛因滥用对机体的严重危害和阐明由一氧化氮等自由基引起、过氧化和脂质过氧化对海洛因滥用者的严重损伤。方法　检测了114例海洛因滥用者（HAs）和100例健康志愿者（HVs）的血浆一氧化氮（P-NO）含量、血浆过氧化脂质（P-LPO）含量及红细胞超氧化物歧化酶（E-SOD）活性、红细胞过氧化氢酶（E-CAT）活性、红细胞谷胱甘肽过氧化物酶（E-GSH-Px）活性和红细胞过氧化脂质（E-LPO）含量并作比较，用直线回归和相关、逐步回归和相关分析了HAs的上述检测值与海洛因滥用史（HAT）和每日海洛因滥用量（DHAQ）之间的关系。结果　与HAs组的上述平均值相比较，HAS组的P-NO、P-LPO、E-LOP平均值均显著升高（P<0.0001），而P-VC、P-VE、P-β-CAR、E-SOD、E-CAT、E-GSH-Px平均值均显著降低（P<0.0001）；直线回归和相关分析表明，随着HAs的HAT延长和DHAQ增加，HAs的P-NO、P-LPO、E-LPO值逐渐升高（P<0.001），而P-VC、P-VE、P-β-CAR、E-SOD、E-CAT、E-GSH-Px值逐渐降低（P<0.001）；逐步回归和相关分析表明，HAs的HAT、DHAQ与P-NO、P-VC、P-VE值相关最密切。结论　HAs体内的氧化抗氧化平衡严重失调，由一氧化氧等自由基引起的氧化、过氧化和脂质过氧化损伤严重加剧，在戒毒中必须给予HAs充分的维生素C、维生素E和β-胡萝卜素等抗氧化剂，以减缓对机体的损伤。
목적　진일보게시해락인람용대궤체적엄중위해화천명유일양화담등자유기인기、과양화화지질과양화대해락인람용자적엄중손상。 방법　검측료114례해락인람용자（HAs）화100례건강지원자（HVs）적혈장일양화담（P-NO）함량、혈장과양화지질（P-LPO）함량급홍세포초양화물기화매（E-SOD）활성、홍세포과양화경매（E-CAT）활성、홍세포곡광감태과양화물매（E-GSH-Px）활성화홍세포과양화지질（E-LPO）함량병작비교，용직선회귀화상관、축보회귀화상관분석료HAs적상술검측치여해락인람용사（HAT）화매일해락인람용량（DHAQ）지간적관계。 결과　여HAs조적상술평균치상비교，HAS조적P-NO、P-LPO、E-LOP평균치균현저승고（P<0.0001），이P-VC、P-VE、P-β-CAR、E-SOD、E-CAT、E-GSH-Px평균치균현저강저（P<0.0001）；직선회귀화상관분석표명，수착HAs적HAT연장화DHAQ증가，HAs적P-NO、P-LPO、E-LPO치축점승고（P<0.001），이P-VC、P-VE、P-β-CAR、E-SOD、E-CAT、E-GSH-Px치축점강저（P<0.001）；축보회귀화상관분석표명，HAs적HAT、DHAQ여P-NO、P-VC、P-VE치상관최밀절。 결론　HAs체내적양화항양화평형엄중실조，유일양화양등자유기인기적양화、과양화화지질과양화손상엄중가극，재계독중필수급여HAs충분적유생소C、유생소E화β-호라복소등항양화제，이감완대궤체적손상。
Objective　To further reveal serious risks of heroin abuse to human body and clarify grave injuries of oxidation, peroxidation and lipoperoxidation induced by nitric oxide and other free radicals to heroin abusers. Methods　Determined and compared plasma levels of nitric oxide (P-NO), vitamin C (P-VC), vitamin E (P-VE), β-carotene (P-β-CAR), lipoperoxides (P-LPO) and erythrocyte activities of superoxide dismutase (E-SOD), catalase (E-CAT), glutathione peroxidase (E-GSH-Px) and erythrocyte level of lipoperoxides (E-LPO) in 137 cases of heroin abusers (HAs) and 100 cases of healthy volunteers (HVs), used linear regression and correlation, stepwise regression and correlation to analyze correlation among heroin-abusing-duration (HAD), daily-heroin-abusing-quantity (DHAQ) with above determination values in the HAs. Results　Compared with the above average values in the HVs group, the average values of P-NO, P-LPO, E-LPO in the HAs group were significantly increased (P<0.0001), the average values of P-VC, P-VE, P-β-CAR, E-SOD, E-CAT and E-GSH-Px were significantly decreased (P<0.0001); the analysis of linear regression and correlation showed that with ascending of the HAD and DHAQ in the HAs, the values of P-NO, P-LPO, E-LPO were gradually increased (P<0.0001), the values of P-VC, P-VE, P-β-CAR, E-SOD, E-CAT, E-GSH-Px were gradually decreased (P<0.0001); the analysis of stepwise regression and correlation suggested that the correlation among the HAD, DHAQ with the values of P-NO, P-VC, P-VE was the closest. Conclusion　The balance between oxidation and antioxidation in the HAs was seriously destroyed, and the injuries induced by nitric oxide and other free radicals, oxidation, peroxidation and lipoperoxidation reactions to the body of HAs gravely exacerbated. In the abstaining from heroin dependence, therefore, it should consider that sufficient quantum antioxidants such as VC, VE and β-CAR are dosed to the HAs so as to abate the injuries to their bodies.