CAJ | 학술논문

目的观察中西医结合治疗小儿支原体肺炎的疗效并探讨支原体肺炎患儿血清中细胞因子的变化.方法采用随机分组法,设立治疗组45例,口服中药加阿奇霉素10 mg/(kgod)静脉点滴,对照组45例,单纯应用阿奇霉素静脉点滴,两组均以7d为1个疗程.并观察两组的有效率、症状体征消失时间及血清中白细胞介素-6(IL-6)、白细胞介素-8(IL-8)和肿瘤坏死因子(TNF-α)的变化.结果两组的总有效率分别为93.33%和73:33%.治疗组疗效明显高于对照组(P<0.05).治疗组在发热消失时间、咳喘及罗音消失时间等方面都明显优于对照组(P<0.05).治疗组细胞因子水平明显低于对照组(P<0.05).结论中西医结合治疗小儿支原体肺炎能缩短病程,提高疗效,明显减轻患儿的痛苦,降低血清中细胞因子含量.
목적 관찰중서의결합치료소인지원체폐염적료효병탐토지원체폐염환인혈청중세포인자적변화.방법 채용수궤분조법,설립치료조45례,구복중약가아기매소10 mg/(kgod)정맥점적,대조조45례,단순응용아기매소정맥점적,량조균이7d위1개료정.병관찰량조적유효솔、증상체정소실시간급혈청중백세포개소-6(IL-6)、백세포개소-8(IL-8)화종류배사인자(TNF-α)적변화.결과 량조적총유효솔분별위93.33%화73:33%.치료조료효명현고우대조조(P<0.05).치료조재발열소실시간、해천급라음소실시간등방면도명현우우대조조(P<0.05).치료조세포인자수평명현저우대조조(P<0.05).결론 중서의결합치료소인지원체폐염능축단병정,제고료효,명현감경환인적통고,강저혈청중세포인자함량.
Objective To observe the therapeutic effect of traditional Chinese medicine (TCM) and Western medicine (WM) treatments on mycoplasmal pneumonia in children and the changes in the serum cytokines. Methods Ninety children with mycoplasmal pneumonia were randomly divided into the treatment group and the control group. TCM was given orally and azithromycin at the daily dose of 10 mg/kg was administered intravenously in the treatment group. In the control group, only intravenous azithromycin was given. After a 7-day treatment, the response rate, time of symptom disappearance, and serum levels of IL-6, IL-8 and TNF-α were observed. Results The total response rate was 93.33% in the treatment group and 73.33% in the control group, showing a significantly better therapeutic effect in the treatment group (P<0.05). The combined treatments also showed better effects in alleviating fever, coughing and rales (P<0.05), and resulted in more obvious reduction in the serum levels of cytokines (P<0.05). Conclusion Combined treatment with TCM and WM produce good therapeutic effects in children with mycoplasmal pneumonia.