CAJ | 학술논문

[目的]探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS) 患者悬雍垂腭咽成形术(UPPP)手术前后胰岛素敏感性的变化.[方法]选择伴血糖紊乱的OSAHS患者20例行多导睡眠监测(PSG)检查及UPPP手术,并于术前及术后6个月进行PSG检查及空腹血糖、糖化血红蛋白、空腹胰岛素水平检测,计算胰岛素敏感指数(ISI)分析其变化关系.[结果]经过UPPP手术治疗后,患者的呼吸暂停低通气指数(AHI)及最低血氧饱和度(LSaO2)明显改善(P<0.05) ,空腹血糖、糖化血红蛋白水平较术前降低,胰岛素敏感性较术前升高(P<0.05).[结论]UPPP手术治疗能改善伴糖代谢紊乱的OSAHS患者低血氧的情况,增加其胰岛素的敏感性.
[목적]탐토조새성수면호흡잠정저통기종합정(OSAHS) 환자현옹수악인성형술(UPPP)수술전후이도소민감성적변화.[방법]선택반혈당문란적OSAHS환자20례행다도수면감측(PSG)검사급UPPP수술,병우술전급술후6개월진행PSG검사급공복혈당、당화혈홍단백、공복이도소수평검측,계산이도소민감지수(ISI)분석기변화관계.[결과]경과UPPP수술치료후,환자적호흡잠정저통기지수(AHI)급최저혈양포화도(LSaO2)명현개선(P<0.05) ,공복혈당、당화혈홍단백수평교술전강저,이도소민감성교술전승고(P<0.05).[결론]UPPP수술치료능개선반당대사문란적OSAHS환자저혈양적정황,증가기이도소적민감성.
[Objective]To explore the change of insulin sensitivity in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) after uvulopalatopharyngoplasty (UPPP) . [Methods]Twenty OSAHS patients were monitored by polysomnography (PSG) . The apnea hypopnea index (AHI) and LSaO2 were evaluated. The levels of fasting plasma glucose,HbA1c, insulin and insulin sensitivity index ( ISI) were measured before and after operation. [Results] The levels of AHI and LSaO2 in the OSAHS patients before UPPP were significantly higher than those after UPPP therapy (P<0.05). The fasting plasma glucose and HbA1c obviously descended and the level of ISI improved compared with that before UPPP therapy (P<0.05). [Conclusion] The UPPP surgical procedures can improve the hypoxia of patients and enhance the ISI.