药品评价
藥品評價
약품평개
DRUG REEVALUATION
2013年
12期
22-24
,共3页
肾损害%抗菌药物%合理用药%药品不良反应
腎損害%抗菌藥物%閤理用藥%藥品不良反應
신손해%항균약물%합리용약%약품불량반응
Kidney Damage%Antibiotic%Rational Drug Application%Adverse Drug Reaction
目的：分析我院住院患者发生抗菌药物相关肾损害的情况，以促进临床合理用药。方法：对我院2000年1月-2011年l2月间住院患者发生的抗菌药物相关肾损害的36例病历资料进行回顾性分析，分析抗菌药物相关肾损害发生的可能原因。结果：临床使用范围较广的β-内酰胺类、氨基糖苷类、喹诺酮类、多肽类、多烯类、抗结核药等抗菌药物均可引起肾损害。肾损害多发生在年龄较大患者、长期用药超疗程患者、不按药品说明书超剂量用药患者中。结论：剂量过大、疗程过长是用药后出现肾损害的主要原因；另外，患者年龄状况也是临床抗菌药物相关肾损害发生的重要原因。因此，合理用药、注意对老年肾功能衰退的患者进行密切监测，是预防抗菌药物相关肾病发生的关键。
目的：分析我院住院患者髮生抗菌藥物相關腎損害的情況，以促進臨床閤理用藥。方法：對我院2000年1月-2011年l2月間住院患者髮生的抗菌藥物相關腎損害的36例病歷資料進行迴顧性分析，分析抗菌藥物相關腎損害髮生的可能原因。結果：臨床使用範圍較廣的β-內酰胺類、氨基糖苷類、喹諾酮類、多肽類、多烯類、抗結覈藥等抗菌藥物均可引起腎損害。腎損害多髮生在年齡較大患者、長期用藥超療程患者、不按藥品說明書超劑量用藥患者中。結論：劑量過大、療程過長是用藥後齣現腎損害的主要原因；另外，患者年齡狀況也是臨床抗菌藥物相關腎損害髮生的重要原因。因此，閤理用藥、註意對老年腎功能衰退的患者進行密切鑑測，是預防抗菌藥物相關腎病髮生的關鍵。
목적：분석아원주원환자발생항균약물상관신손해적정황，이촉진림상합리용약。방법：대아원2000년1월-2011년l2월간주원환자발생적항균약물상관신손해적36례병력자료진행회고성분석，분석항균약물상관신손해발생적가능원인。결과：림상사용범위교엄적β-내선알류、안기당감류、규낙동류、다태류、다희류、항결핵약등항균약물균가인기신손해。신손해다발생재년령교대환자、장기용약초료정환자、불안약품설명서초제량용약환자중。결론：제량과대、료정과장시용약후출현신손해적주요원인；령외，환자년령상황야시림상항균약물상관신손해발생적중요원인。인차，합리용약、주의대노년신공능쇠퇴적환자진행밀절감측，시예방항균약물상관신병발생적관건。
Objective: By analyzing the information of the inpatients who had antibiotic-associated kidney damage in our hospital, this manuscript tried to remind the clinicians having a reasonable antibiotic-usage. Methods: We had a retrospective analysis of the medical records on 36 inpatients who had antibiotic-associated kidney damage during January 2000 to December 2011 in our hospital, and analyzed the possible causes of antibiotic-associated kidney damage. Results: Those antibiotics which had a wide clinical use such as Lactams, Aminoglycosides, Quinolones, Polypeptides, Polyene and Anti-TB drugs etc., can cause kidney damage. And the kidney damage mostly occurred in patients who are older, and/or with long-term and ultra-treatment medication, and patients who do not follow the drug-instruction and had an excessive dose of medication. Conclusion: Excessive doses and long-term medication are the main reasons for kidney damage; In addition, patient's age is also an important reason that antibiotic-nephropathy occurred. Therefore, reasonable usage of antibiotics and close monitoring of older patients with kidney function decline, are the key methods to prevent antibiotic-nephropathy.
