CAJ | 학술논문

目的观察补肾宁心益经丸治疗卵巢早衰(premature ovarian Failure,POF)的临床疗效.方法选择60例肾虚型POF患者,随机分为两组各30例.治疗组口服补肾宁心益经丸治疗,对照组口服六味地黄丸,6个月为1个疗程.观察两组治疗前后临床症状、血清卵泡刺激素(FSH)及雌二醇(E2)水平的变化.结果两组月经情况均有显著改善(P<0.01);治疗组血清FSH明显降低、E2明显升高,较治疗前有显著性差异(P<0.01).治疗组总有效率为70%(21例),对照组为40%(12例),两组比较有显著性差异(P<0.01).结论补肾宁心益经丸能明显改善POF患者的临床症状和血清内分泌水平.
목적 관찰보신저심익경환치료란소조쇠(premature ovarian Failure,POF)적림상료효.방법 선택60례신허형POF환자,수궤분위량조각30례.치료조구복보신저심익경환치료,대조조구복륙미지황환,6개월위1개료정.관찰량조치료전후림상증상、혈청란포자격소(FSH)급자이순(E2)수평적변화.결과 량조월경정황균유현저개선(P<0.01);치료조혈청FSH명현강저、E2명현승고,교치료전유현저성차이(P<0.01).치료조총유효솔위70%(21례),대조조위40%(12례),량조비교유현저성차이(P<0.01).결론 보신저심익경환능명현개선POF환자적림상증상화혈청내분비수평.
Objective The purposes of the present study are to investigate the effects and mechanisms of Bu Shen Ning Xin Yi Jing Pill on premature ovarian failure (POF) through a clinical study. Methods Sixty women with POF were administered and randomized into the treatment group and the control group. Every group had thirty cases. Patients in the treatment and control groups were requested to have the Bu Shen Ning Xin Yi Jing Pill and the Liu Wei Di Huang Pill, respectively. Six-month duration was considered as a therapeutic course. The serum levels of follicle stimulating hormone (FSH) and estradiol (E2) were determined by the chemistry luminescence method. Differences between the treatment and control groups were investigated.Results Improved menstruation were revealed in both groups and the treatment group showed significant improvement than the control group (P<0.01). In the treatment group, serum FSH levels sharply dropped after treatment, while the serum E2 levels significantly elevated compared with those of prior-treatment (P<0.01) . The total effective rate in the treatment group was 70% (21 cases), whereas 40% in the control group (12 cases). The difference had statistical significance (P<0.01) .Conclusion The BuShen NingXin YiJing Pill is effective in the treatment of premature ovarian failure via significant improvements in the clinical symptoms and balance of the endocrine hormones.