CAJ | 학술논문

抗原特异性的免疫记忆是获得性免疫的重要特征.初次感染后免疫系统对特异性抗原建立免疫记忆,再次遇到同种抗原后能够产生更快速和高强度的免疫应答.构建疫苗的理想目标是诱导长效免疫记忆的产生.目前,疟疾的预防和治疗策略不断受阻于耐药疟原虫虫株出现等问题.免疫记忆难以长期有效维持是疟疾感染的主要特征.然而,诱导、维持和活化免疫记忆细胞的分子机制尚未充分阐明.该文对疟疾免疫记忆研究进展作一综述,以期为疟疾疫苗的研制开发提供新的理论依据.
항원특이성적면역기억시획득성면역적중요특정.초차감염후면역계통대특이성항원건립면역기억,재차우도동충항원후능구산생경쾌속화고강도적면역응답.구건역묘적이상목표시유도장효면역기억적산생.목전,학질적예방화치료책략불단수조우내약학원충충주출현등문제.면역기억난이장기유효유지시학질감염적주요특정.연이,유도、유지화활화면역기억세포적분자궤제상미충분천명.해문대학질면역기억연구진전작일종술,이기위학질역묘적연제개발제공신적이론의거.
The hallmark of adaptive immunity is antigen-specific immunological memory.Immunological memory is a phenomenon that has been exposed to a pathogen and survived the infection the experience is ' remembered' by the immune system.Upon re-exposure to the same pathogen an individual's immune response is more rapid and stronger so that the individual may experience no clinical systems of the infection.Indeed,all vaccines are predicated on the phenomenon of immunological memory.Malaria control has been continuously hampered by the re-emerging parasite resistance to newly introduced drugs.An important feature of malaria infection was difficult to effectively maintain long-term immune memory.However,the molecular mechanisms of induction,maintain and activation of memory cells remain unclear.Herein,this review highlighted the key aspects of malaria immune memory so as to provide theoretical basis for the development of effective malaria vaccines.