中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2008年
10期
961-963
,共3页
非小细胞肺癌%细胞增殖抑制基因%p21wAF1蛋白
非小細胞肺癌%細胞增殖抑製基因%p21wAF1蛋白
비소세포폐암%세포증식억제기인%p21wAF1단백
Non-small cell lung cancer%Hyperplasia suppressor gene/Mitofusin2%P21 WAF1 protein
目的 探讨细胞增殖抑制基因(HSG/Mfn2)、p21WAF1蛋白在非小细胞肺癌中的表达及相关性.方法 采用免疫组化SP法检测92例非小细胞肺癌中HSG/Mfn2、p21WAF1蛋白的表达.结果 HSG/Mfn2在肺鳞癌、腺癌、非癌肺组织中吸光度值分别为15.06±2.73、12、21±2.96、10.36±3.60,差异有统计学意义(P<0.05),并与肺癌分化程度有关.p21WAF1蛋白在肺鳞癌、腺癌、非癌肺组织中吸光度值分别为3.16±0.98、3.44±0.22、0.06±0.32,肺鳞癌和腺癌组织与非癌组织比较差异均有统计学意义(均P<0.05),与分化程度、淋巴结转移有关.结论 HSG/Mfn2,p21WAF1蛋白与肺癌发生、发展密切相关.二者在肺癌组织中的表达呈正相关.
目的 探討細胞增殖抑製基因(HSG/Mfn2)、p21WAF1蛋白在非小細胞肺癌中的錶達及相關性.方法 採用免疫組化SP法檢測92例非小細胞肺癌中HSG/Mfn2、p21WAF1蛋白的錶達.結果 HSG/Mfn2在肺鱗癌、腺癌、非癌肺組織中吸光度值分彆為15.06±2.73、12、21±2.96、10.36±3.60,差異有統計學意義(P<0.05),併與肺癌分化程度有關.p21WAF1蛋白在肺鱗癌、腺癌、非癌肺組織中吸光度值分彆為3.16±0.98、3.44±0.22、0.06±0.32,肺鱗癌和腺癌組織與非癌組織比較差異均有統計學意義(均P<0.05),與分化程度、淋巴結轉移有關.結論 HSG/Mfn2,p21WAF1蛋白與肺癌髮生、髮展密切相關.二者在肺癌組織中的錶達呈正相關.
목적 탐토세포증식억제기인(HSG/Mfn2)、p21WAF1단백재비소세포폐암중적표체급상관성.방법 채용면역조화SP법검측92례비소세포폐암중HSG/Mfn2、p21WAF1단백적표체.결과 HSG/Mfn2재폐린암、선암、비암폐조직중흡광도치분별위15.06±2.73、12、21±2.96、10.36±3.60,차이유통계학의의(P<0.05),병여폐암분화정도유관.p21WAF1단백재폐린암、선암、비암폐조직중흡광도치분별위3.16±0.98、3.44±0.22、0.06±0.32,폐린암화선암조직여비암조직비교차이균유통계학의의(균P<0.05),여분화정도、림파결전이유관.결론 HSG/Mfn2,p21WAF1단백여폐암발생、발전밀절상관.이자재폐암조직중적표체정정상관.
Objective To investigate the expression of hyperplasia suppressor gene(HSG)/mitofusin 2 (Mfn2)and P21 WAF1 in non-small cell lung cancer(NSCLC).Methods The expression of(HSG/Mfn2)and P21 WAF1 was detected in 92 cases of NSCLC samples by immunohistochemistry(SP).Results The absorptance value of the expression of HSG/Mfn2 in squamous cell carcinoma,adenocarcinoma,and non-cancer tissue were 15.06±2.73,12.21±2.96 and 10.36±3.60,respectively(P<0.05),and they were associated with tumor differentiation.The absorptanee valtue of the expression of P21 WAF1 in squamous cell carcinoma,adenocarcinoma,and non-cancer tissue were 3.16±0.98,3.44±0.22,0.06±0.32.The expression of P21 WAF1 in squamous cell carcinoma and adenocarcinoma Was higher than that in non-cancer tissue(P<0.05),and was closely associated with tumor differ-entiation and lymph node metastasis.Conclusion HSG/Mfn2,P21WAF1 is closely related to the pathogenesis and development of lung cancer.There is positive correlation between the HSG/Mfn2 and P2l WAF1 in lung cancer.
