CAJ | 학술논문

目的探讨左炔诺孕酮宫内节育系统(LNG-IUS)治疗子宫腺肌病患者的临床疗效及对其卵巢功能的影响.方法观察80例子宫腺肌病患者放置LNG-IUS前、后1、3、6及12个月月经量评分、痛经程度评分、子宫大小、肝功能、血清CA125、EMAb、性激素、血糖及血脂水平变化.结果放置LNG-IUS后,痛经缓解明显,6个月内痛经症状基本消失.置环后6、12个月月经量明显减少[(40.0±15)ml、(28±7)ml],与置环前[(200.0±60)ml]比较差异均有统计学意义(P＜0.01),血清CA125水平和EMAb阳性率较治疗前明显降低[CA125:(50.69±10.00)IU/L vs(18.60±3.55)IU/L;EMAb:80.0%vs 3.8%,P＜0.05];置环6、12个月时,子宫体积缩小不明显,肝功能、血糖、血脂、血清促卵泡生成激素、促黄体生成素平分别与放置前比较,差异均无统计学意义(P＞0.05).结论 LNG-IUS治疗子宫腺肌病患者疗效好,不良反应少,且对其卵巢功能无明显影响.
목적 탐토좌결낙잉동궁내절육계통(LNG-IUS)치료자궁선기병환자적림상료효급대기란소공능적영향.방법 관찰80례자궁선기병환자방치LNG-IUS전、후1、3、6급12개월월경량평분、통경정도평분、자궁대소、간공능、혈청CA125、EMAb、성격소、혈당급혈지수평변화.결과 방치LNG-IUS후,통경완해명현,6개월내통경증상기본소실.치배후6、12개월월경량명현감소[(40.0±15)ml、(28±7)ml],여치배전[(200.0±60)ml]비교차이균유통계학의의(P＜0.01),혈청CA125수평화EMAb양성솔교치료전명현강저[CA125:(50.69±10.00)IU/L vs(18.60±3.55)IU/L;EMAb:80.0%vs 3.8%,P＜0.05];치배6、12개월시,자궁체적축소불명현,간공능、혈당、혈지、혈청촉란포생성격소、촉황체생성소평분별여방치전비교,차이균무통계학의의(P＞0.05).결론 LNG-IUS치료자궁선기병환자료효호,불량반응소,차대기란소공능무명현영향.
Objective To investigate the clinical efficacy of levonorgestrel- releasing intrauterine system (LNG-IUS) in the treatment of adenomyosis and the influence of ovarian function. Methods Eighty patients with adenomyosis were followed up for 0, 1, 3, 6, 12 months after treating with LNG-IUS. The menstrual blood volume, dysmenorrheal, size of uteri, CA125 and EMAb level, hepatic function, serum glucose and serum lipids were observed and evaluated. Serum- levels of FSH and LH were tested before insertion and followed up for 6, 12 months after insertion, respectively. Results After inserting LNG-IUS,dysmenorrhea was obviously alleviated, and it was significantly decreased after 6 months. The menstrual blood volume was (200. 0 ±60)ml, (40. 0 ± 15)ml and (28 ±7)ml in 0, 6, 12 months after the insertion.Serum CA125 and positive rate of EMAb also significantly reduced [CA125: (50. 69 ± 10. 00) IU/L vs (18. 60 ±3.55)IU/L;EMAb:80. 0% vs 3. 8%, P ＜0. 05]. The volume of uterus reduced without significant changed (P ＞0. 05). There were little changes in the levels of hepatic function, serum glycosum, serum lipids, FSH and LH at 6 and 12 months after LNG-IUS(P ＞ 0. 05). Conclusions LUG-IUS is an effective and safe therapy for adenomyosis with dysmenorrheal and menorrhagia, and it has no significant effects on ovarian function.