CAJ | 학술논문

目的探讨多西紫杉醇联合顺铂(DDP)同期放疗治疗局部晚期食管癌的疗效及其毒副反应.方法 90例局部晚期食管鳞状细胞癌患者随机分为分为多西紫杉醇联合DDP同期放疗组(简称DP组)和5-氟尿嘧啶(5-Fu)联合DDP 同期放疗组(简称PF组),化疗每4周1次,共4个疗程;放疗剂量为50.4 Gy/28次.结果 DP组和PF组患者的有效率分别为84.5%和71.1%,差异有统计学意义(P=0.025).DP组患者的中位生存期为21.5个月,PF组患者的中位生存期为16.0个月,差异有统计学意义(P=0.0278).DP组和PF组患者的3年生存率分别为23.9%和12.1%.DP组和PF组患者的毒副反应发生率无显著差异.结论 DP组较PF组有更好的有效率和长期生存率,且毒副反应并未增加.对于无法手术的局部中晚期食管癌患者,可采用多西紫杉醇联合顺铂同期放疗的治疗方法,以期获得更好的疗效及长期生存.
목적 탐토다서자삼순연합순박(DDP)동기방료치료국부만기식관암적료효급기독부반응.방법 90례국부만기식관린상세포암환자수궤분위분위다서자삼순연합DDP동기방료조(간칭DP조)화5-불뇨밀정(5-Fu)연합DDP 동기방료조(간칭PF조),화료매4주1차,공4개료정;방료제량위50.4 Gy/28차.결과 DP조화PF조환자적유효솔분별위84.5%화71.1%,차이유통계학의의(P=0.025).DP조환자적중위생존기위21.5개월,PF조환자적중위생존기위16.0개월,차이유통계학의의(P=0.0278).DP조화PF조환자적3년생존솔분별위23.9%화12.1%.DP조화PF조환자적독부반응발생솔무현저차이.결론 DP조교PF조유경호적유효솔화장기생존솔,차독부반응병미증가.대우무법수술적국부중만기식관암환자,가채용다서자삼순연합순박동기방료적치료방법,이기획득경호적료효급장기생존.
Objective To investigate the therapeutical effect and side-effect of docetaxel combined with cisplatin (DDP) on the treatment of local advanced esophageal cancer with concomitant radiation therapy. Methods Ninety patients with LOCAL advanced esophageal squamous cell carcinoma were divided into two groups: ( DDP +5-Fu) group and (docetaxel + DDP) group. Chemotherapy was carried out every 4 weeks for a total of 4 courses. The radiation dose was 50.4 Gy/28 FX. Results The median survival time of patients in the (DDP +5-Fu) group was 16 months and that in (docetaxel + DDP) group was 21 months (P =0.0278). The 3-year survival rate in the (docetaxel + DDP) group was obviously higher than that inthe (DDP+5-Fu) group (23.9% vs. 12.1%). The ORR in (docetaxel +DDP) group (84.5%) was significantly higher than that in the (DDP +5-Fu) group (71.1%) (P =0.025 ). No significant differenceswere observed in the incidence of side-effects in the two groups. Conclusions The conventional dose chemotherapy of docetaxel + DDP with concomitant radiation therapy showed a better partial remission rate and long-term survival rate for the treatment of local advanced esophageal cancer than the traditional chemotherapy (DDP +5-Fu) with concomitant radiation therapy and the side-effects are not increased.