中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2010年
23期
1597-1601
,共5页
岳丽%虞培敏%赵德豪%吴冬燕%吴洵昳%朱国行%洪震
嶽麗%虞培敏%趙德豪%吳鼕燕%吳洵昳%硃國行%洪震
악려%우배민%조덕호%오동연%오순질%주국행%홍진
癫痫%生活质量%影响因素%女性%中老年
癲癇%生活質量%影響因素%女性%中老年
전간%생활질량%영향인소%녀성%중노년
Epilepsy%Quality of life%Health status indicators%Female%Aged
目的 研究癫痫患者生活质量的影响因素并比较男性和女性、青年和中老年癫痫患者生活质量影响因素的差异.方法 收集自2004年10月至2008年11月就诊于华山医院神经内科门诊的癫痫患者,并完成癫痫患者生活质量量表(QOLIE-31)、抗癫痫药物不良反应量表(SEP)、焦虑自评量表(SAS)和汉密尔顿抑郁量表(HAMD)的评定.应用多元逐步回归分析各影响因素与生活质量的关系及其组间差异.结果 共完成204例癫痫患者,其中青年患者160例,中老年患者44例,女性79例,男性125例.女性与男性患者、中老年与青年患者的QOLIE-31总分差异无统计学意义.SEP 评分(β=-0.395,P=0.000)和SAS评分(β=-0.152,P=0.016)是癫痫患者QOLIE-31总分的重要预测因素.性别比较,病程(β=-0.165,P=0.028)和发作频率(β=-0.284,P=O.001)分别与男性患者QOLIE-31总分和"社会活动"得分相关,用药数量与女性患者QOLIE-31总分(β=-0.238,P=0.006)和多个分项分相关.年龄比较,发作频率(β=-0.284,P=0.000)和学历(β=0.203,P=0.005)与青年患者QOLIE-31"社会活动"得分相关,用药数量(β=-0.363,P=0.004)与中老年患者QOLIE-31总分相关.结论 药物不良反应和用药数量对女性和中老年患者的生活质量影响更为显著;发作频率等疾病本身因素对男性和青年癫痫患者的生活质量影响更大.
目的 研究癲癇患者生活質量的影響因素併比較男性和女性、青年和中老年癲癇患者生活質量影響因素的差異.方法 收集自2004年10月至2008年11月就診于華山醫院神經內科門診的癲癇患者,併完成癲癇患者生活質量量錶(QOLIE-31)、抗癲癇藥物不良反應量錶(SEP)、焦慮自評量錶(SAS)和漢密爾頓抑鬱量錶(HAMD)的評定.應用多元逐步迴歸分析各影響因素與生活質量的關繫及其組間差異.結果 共完成204例癲癇患者,其中青年患者160例,中老年患者44例,女性79例,男性125例.女性與男性患者、中老年與青年患者的QOLIE-31總分差異無統計學意義.SEP 評分(β=-0.395,P=0.000)和SAS評分(β=-0.152,P=0.016)是癲癇患者QOLIE-31總分的重要預測因素.性彆比較,病程(β=-0.165,P=0.028)和髮作頻率(β=-0.284,P=O.001)分彆與男性患者QOLIE-31總分和"社會活動"得分相關,用藥數量與女性患者QOLIE-31總分(β=-0.238,P=0.006)和多箇分項分相關.年齡比較,髮作頻率(β=-0.284,P=0.000)和學歷(β=0.203,P=0.005)與青年患者QOLIE-31"社會活動"得分相關,用藥數量(β=-0.363,P=0.004)與中老年患者QOLIE-31總分相關.結論 藥物不良反應和用藥數量對女性和中老年患者的生活質量影響更為顯著;髮作頻率等疾病本身因素對男性和青年癲癇患者的生活質量影響更大.
목적 연구전간환자생활질량적영향인소병비교남성화녀성、청년화중노년전간환자생활질량영향인소적차이.방법 수집자2004년10월지2008년11월취진우화산의원신경내과문진적전간환자,병완성전간환자생활질량량표(QOLIE-31)、항전간약물불량반응량표(SEP)、초필자평량표(SAS)화한밀이돈억욱량표(HAMD)적평정.응용다원축보회귀분석각영향인소여생활질량적관계급기조간차이.결과 공완성204례전간환자,기중청년환자160례,중노년환자44례,녀성79례,남성125례.녀성여남성환자、중노년여청년환자적QOLIE-31총분차이무통계학의의.SEP 평분(β=-0.395,P=0.000)화SAS평분(β=-0.152,P=0.016)시전간환자QOLIE-31총분적중요예측인소.성별비교,병정(β=-0.165,P=0.028)화발작빈솔(β=-0.284,P=O.001)분별여남성환자QOLIE-31총분화"사회활동"득분상관,용약수량여녀성환자QOLIE-31총분(β=-0.238,P=0.006)화다개분항분상관.년령비교,발작빈솔(β=-0.284,P=0.000)화학력(β=0.203,P=0.005)여청년환자QOLIE-31"사회활동"득분상관,용약수량(β=-0.363,P=0.004)여중노년환자QOLIE-31총분상관.결론 약물불량반응화용약수량대녀성화중노년환자적생활질량영향경위현저;발작빈솔등질병본신인소대남성화청년전간환자적생활질량영향경대.
Objective To determine factors associated with quality of life(QOL)in epileptics and the variations between men and women,younger and older people.Methods A total of 204 patients(160 younger,49 older;125 men,79 women)were interviewed by the quality of life in epilepsy-31(QOLIE-31),side effect profile(SEP),self-rating anxiety scale(SAS)and Hamilton depression scale(HAMD).Medical and socio-demographic data were acquired from patient records.Multivariate linear regressive analyses were used to determine the set of best predictors of composite QOLIE-31 score.Results No statistical difference was revealed in QOLIE-3l overall score either between younger and older patients or between men and women.Among all patients,regressive analyses revealed that SEP(β=-0.395,P=0.000)and SAS(β=-0.152,P=0.016)were two strong predictors of QOLIE-31 overall score.Grouped by gender,among men,epilepsy duration(β:-0.165,P=0.028)and seizure frequency(β=-0.284,P=0.001) respectively associated with QOLIE-31 overall score and"social function"score while the number of AEDs(antiepileptic drugs)substantially correlated with QOLIE-31 overall score among women (β=-0.238,P=0.006).Grouped by ages,seizure frequency(β=-0.284,P=0.000) and education level(β=0.203,P=0.005)predicted QOLIE-31"social function"score only among younger patients;among older patients,a significant association were found between the number of AEDs and QOLIE-31 overall score(β=-0.363,P=0.004).Conclusion Side effects of AEDs and number of AEDs exert greater effect on QOL in women and older patients.And such seizure-related vailables as epileptic duration and seizure frequency influence QOL only among men and younger patients.
