CAJ | 학술논문

目的用研磨法制备槲皮素-羟丙基-β-环糊精包合物,测定包合常数及包合过程热力学参数,并对物相进行鉴定.方法采用研磨法制备包合物,对其包合常数进行测定,利用差热分析(DSC)、红外光谱分析(IR)、粉末X衍射(X-ray)、扫描电镜(SEM)等方法对其进行物相鉴定,以溶解度和溶出实验考察其溶解性质.结果所制备的包合物溶解度较槲皮素纯品增加约37倍,5分钟的溶出百分率较槲皮素纯品提高近10倍.DSC结果表明包合物中槲皮素吸热峰位前移;IR图谱槲皮素羰基吸收峰产生位移;X-衍射图谱包合物中槲皮素吸收峰消失;电镜扫描照片包合物中未见槲皮素晶体,说明形成新物相.结论研磨可使槲皮素与羟丙基β环糊精形成包合物,改善槲皮素的溶解性.
목적용연마법제비곡피소-간병기-β-배호정포합물,측정포합상수급포합과정열역학삼수,병대물상진행감정.방법채용연마법제비포합물,대기포합상수진행측정,이용차열분석(DSC)、홍외광보분석(IR)、분말X연사(X-ray)、소묘전경(SEM)등방법대기진행물상감정,이용해도화용출실험고찰기용해성질.결과소제비적포합물용해도교곡피소순품증가약37배,5분종적용출백분솔교곡피소순품제고근10배.DSC결과표명포합물중곡피소흡열봉위전이;IR도보곡피소탄기흡수봉산생위이;X-연사도보포합물중곡피소흡수봉소실;전경소묘조편포합물중미견곡피소정체,설명형성신물상.결론연마가사곡피소여간병기β배호정형성포합물,개선곡피소적용해성.
Aim To prepare and characterize the QURC-HP-β-CD inclusion complexes and investigate the thermodynamic parameters of the process. Methods QURC-HP-β-CD inclusion complexes were prepared by the grinding method. The equilibrium inclusion constants and thermodynamic parameters were determinated by phase solubility analysis. Dissolution tests were performed to study the dissolution rate of inclusion complexes. The formation of inclusion complexes was confirmed by differential scanning calorimetry ( DSC), infrared spectroscopy ( IR), powder X-ray diffractometry (PXRD) and scanning electron microscopy (SEM). Results The aqueous solubility of quercetin was greatly increased ( about 37 folds) by inclusion technique, and the initial dissolution rate was markedly improved (10 folds) in the first 5 min. The results of DSC and SEM photographs showed that quercetin crystal disappeared in inclusion complexes, which indicated the formation of new phase. FT-IR spectra showed that the carbonyl absorption band of quercetin was shifted. PXRD showed that the diffraction peak of quercetin crystal disappeared. Conclusion QURC-HP-β-CD inclusion complexes are produced by the grinding method. The solubility of quercetin is improved by the inclusion technique.