CAJ | 학술논문

目的对Von clauss法和PT衍算法(PT-der法)定量测定纤维蛋白原(Fbg)进行实验评价。方法低、中、高值质控血浆的批内精密度实验，对临床样本测定的统计学分析。结果 Von clauss法和PT-der法对样本的测定只有Fbg含量在2～3 g/L时，测定结果才无统计学差异，在2 g/L＞Fbg＞3 g/L时均有显著性差异，PT-der法测得的结果偏高。结论建议在临床应用中不要以PT-der法代替Von clauss法进行Fbg测定。
목적대Von clauss법화PT연산법(PT-der법)정량측정섬유단백원(Fbg)진행실험평개。방법저、중、고치질공혈장적비내정밀도실험，대림상양본측정적통계학분석。결과 Von clauss법화PT-der법대양본적측정지유Fbg함량재2～3 g/L시，측정결과재무통계학차이，재2 g/L＞Fbg＞3 g/L시균유현저성차이，PT-der법측득적결과편고。결론건의재림상응용중불요이PT-der법대체Von clauss법진행Fbg측정。
Aim　A preliminary study was made to evaluate two fibrinogen determination methods:Von clauss method and Prothrombin time derived method.Methods　Three level of control plasma were determined repeatly to evaluate the precision of two methods.The result that obtained by two methods from daily work sample were statistically evaluated.Result　There hadn't statistically significant difference by t-test (P＜0.05) only when the concentration of fibrinogen is between 2 and 3g/L.For plasma with lower (＜2g/L) or with high fibrinogen concentration (＞3g/L ),the values had statistically significant difference. The PT-derived method tend to overestimate the fibrinogen results compared to the Von clauss method.Conclusion　In daily work,PT-der method should not replace the Von clauss method in the fibrinogen assay.