CAJ | 학술논문

目的　通过动物实验观察丹参和甘露醇对肢体缺血再灌注所致心、肝、肾、胰损伤的保护作用。方法　150只Wistar大鼠随机分成正常对照组，缺血2 h，缺血3 h，缺血3 h分别用丹参和甘露醇共5个组。实验组于缺血、再灌注1，2，3和24 h取材光镜对比观察。结果　肢体缺血和再灌注后，实验组心、肝、肾、胰毛细血管扩张、充血、中性白细胞浸润、细胞变性、组织损伤。用丹参和甘露醇组的病变明显轻于未用药组。结论　丹参和甘露醇都有减轻肢体缺血再灌注所致远处器官损伤作用。
목적　통과동물실험관찰단삼화감로순대지체결혈재관주소치심、간、신、이손상적보호작용。방법　150지Wistar대서수궤분성정상대조조，결혈2 h，결혈3 h，결혈3 h분별용단삼화감로순공5개조。실험조우결혈、재관주1，2，3화24 h취재광경대비관찰。결과　지체결혈화재관주후，실험조심、간、신、이모세혈관확장、충혈、중성백세포침윤、세포변성、조직손상。용단삼화감로순조적병변명현경우미용약조。결론　단삼화감로순도유감경지체결혈재관주소치원처기관손상작용。
Objective　To observe the protective effect of Radix Salvia Miltiorrhiza (RSM) and mannitol on heart, liver, kideny and pancreas injury after lower limb ischemic reperfusion. Method　One hundred and fifty rats were divided into control group, ischemia 2 hours group, ischemia 3 hours group, ischemia 3 hours group treated with RSM and ischemia 3 hours group with mannitol. The histological observation of the heart, liver, kideny and pancreas were undertaken at 0, 1, 2, 3 and 24 hours after reperfusion. Result　It was found that microvascular congestion, infiltrating of polymorphonuclear nutrophil (PMN), cell degeneration and tissue damages was observed in experimental groups at 0, 1, 2, 3 and 24 hours after reperfusion. There was a significant lessening of these remote organ injury in group treated with RSM and Mannitol. Conclusion　These suggest that RSM and mannitol can alleviat the heart, liver, kideny and pancreas injury after lower limb ischemic reperfusion.