CAJ | 학술논문

目的观察并了解东菱精纯克栓酶对荷瘤裸鼠全血流变学参数值的影响。方法采用锥板式粘度计对移植胃癌和鼻咽癌荷瘤裸鼠使用东菱精纯克栓酶前后的全血粘度进行检测，并进行统计学分析。结果使用东菱精纯克栓酶后胃癌裸鼠血液流变学各项指标皆于用药前差异显著(P＜0.01)，鼻咽癌裸鼠用药后全血低切粘度低于用药前(P＜0.01)，其它指标无明显改变(P＞0.05)。结论使用东菱精纯克栓酶对荷瘤裸鼠的血液流变学参数有明显改善，提示有可能将其应用于临床预防肿瘤转移及扩散。
목적관찰병료해동릉정순극전매대하류라서전혈류변학삼수치적영향。방법채용추판식점도계대이식위암화비인암하류라서사용동릉정순극전매전후적전혈점도진행검측，병진행통계학분석。결과사용동릉정순극전매후위암라서혈액류변학각항지표개우용약전차이현저(P＜0.01)，비인암라서용약후전혈저절점도저우용약전(P＜0.01)，기타지표무명현개변(P＞0.05)。결론사용동릉정순극전매대하류라서적혈액류변학삼수유명현개선，제시유가능장기응용우림상예방종류전이급확산。
Objective To observe the effects of Batroxobin on the hemorheology in the whole blood of Nude mice with gastric and nasopharynegal carcinoma. Methods The blood viscosity values of the nude mice with transplantable gastric carcinoma (GC) and nasopharyngeal cacinoma (NPC) were tested simultaneously by means of the cone and plate viscometer and hemorheology in the blood among them were obtained by unitary linearly regression. Results After the use of the Batroxobin, hemorheological values are significantly come down in both groups ( P ＜ 0.01) .The whole blood viscosity at high shear rate value is come down significantly in the (GC) group ( P ＜ 0.01).but no significant changes found in the (NPC) group ( P ＞0.05).Conclusion There is a significant improvement in the hemorheological parameters and it suggests that the clinical usage of the Batroxobin may be valuable in the prevention of the metastasis and spread of tumors.