CAJ | 학술논문

目的：观察70味珍珠丸对“血瘀”大鼠血液流变学的影响，了解其活血化瘀作用。方法：ig 70味珍珠丸，并用冰水浴刺激和sc肾上腺素，制造大鼠“血瘀”模型，测定血液流变学各项指标。结果：70味珍珠丸可明显降低“血瘀”大鼠低切变率下的全血粘度、全血还原粘度(P＜0.05)、红细胞聚集指数(P＜0.05，P＜0.01)及红细胞压积(P＜0.05)；同时也有降低中、高切变率大鼠全血粘度、全血还原粘度、纤维蛋白原以及延长凝血时间和减少血小板数的趋势(P＞0.05)。另外不改变正常大鼠凝血酶原时间和出血时间。结论：本品对“血瘀”大鼠可抑制红细胞聚集和凝固，降低血液粘稠度和浓度，具有一定的活血化瘀作用。但不影响正常的凝血功能。
목적：관찰70미진주환대“혈어”대서혈액류변학적영향，료해기활혈화어작용。방법：ig 70미진주환，병용빙수욕자격화sc신상선소，제조대서“혈어”모형，측정혈액류변학각항지표。결과：70미진주환가명현강저“혈어”대서저절변솔하적전혈점도、전혈환원점도(P＜0.05)、홍세포취집지수(P＜0.05，P＜0.01)급홍세포압적(P＜0.05)；동시야유강저중、고절변솔대서전혈점도、전혈환원점도、섬유단백원이급연장응혈시간화감소혈소판수적추세(P＞0.05)。령외불개변정상대서응혈매원시간화출혈시간。결론：본품대“혈어”대서가억제홍세포취집화응고，강저혈액점주도화농도，구유일정적활혈화어작용。단불영향정상적응혈공능。
OBJECTIVE：To obeserve the effect of RNSP on blood rheology in increased blood viscosity rat and analysis its machanism that is related to cerebral vascular.METHOD:The animal model of acute blood stagnation was formed quickly in rats by injected Adrenaline and cold water stimulation,the parameter of blood rheology were measured.RESULTS:RNSP 0.5g/kg and 1g/kg markedly decreased whole blood viscosity(ηb) and whole blood reduced viscosity(ηr) at shear rates of 10s-1,50s-1 and 120s-1,specially at low shear rate,deduced the aggregation inder of RBC(AI) and hemotocrit(Hct).At the same time,no effects on bleeding time and clotting time were observed.The effect of RNSP 1g/kg is similar to that of injectio salvia miltiorrhiza(SM).CONCLUSION:RNSP had the inhibition effect on the aggregate and coagulate function of Red blood cells,and would decrease the blood viscosities.It promoted the blood circulation to remove blood stasis,but had no effect on bleeding time and clotting,in normal animals.