CAJ | 학술논문

用188W/188Re发生器淋洗得到的188Re示踪剂分别制备了无载体和有载体的188Re-AEDP(1-氨基-亚乙基- 1,1-二膦酸)，研究了这两种标记化合物在小鼠体内的分布，并讨论了载体对188Re-AEDP生物分布的可能影响。实验结果指出有载体的188Re-AEDP有更高的骨摄取率和T /NT比，并且血液清除快，因而是一个有潜在价值的骨疼痛治疗剂。
용188W/188Re발생기림세득도적188Re시종제분별제비료무재체화유재체적188Re-AEDP(1-안기-아을기- 1,1-이련산)，연구료저량충표기화합물재소서체내적분포，병토론료재체대188Re-AEDP생물분포적가능영향。실험결과지출유재체적188Re-AEDP유경고적골섭취솔화T /NT비，병차혈액청제쾌，인이시일개유잠재개치적골동통치료제。
Carrier-free 188Re- and carrier-added 188Re-AEDP (1-amino-ethylene diphosphonic acid) were synthesized by using 188Re tracer eluted from 188W/188Re generator. The distributions of both 188Re-labelled compounds in rats were measured and the dependence of their biodistribution on the rhenium carrier was studied. The results showed much higher skeletal uptake, T/NT and more rapid blood clearance when using carrier-added 188Re. It was found that carrier has effect on the skeletal uptake of 188Re-AEDP. Thus 188Re-AEDP is a potential radiopharmaceutical which may be therapeutically beneficial to bone metastases