CAJ | 학술논문

研究旨在探讨与膀胱癌发生危险有关的谷胱甘肽S-转移酶(GSTs)M1和T1基因型的多态性的分布与有联苯胺接触的膀胱癌高危人群医学监护结果的关系。将上海市染料化工行业的联苯胺接触人群按监护的巴氏分级结果分组，分别与健康对照人群作各种基因型构成比的比较，并进行各组间的构成比趋势分析。结果发现，接触人群内监护史中最大级别≤2级组的T1 0/0型、M1 0/0型、和T1 0/0-M1 0/0型和2.5级组的M1 0/0型、T1 0/0-M1 0/0型的构成比均显著高于对照人群；平均级别在1.7级以下者中T1 0/0型和T1 0/0-M1 0/0型构成比均显著高于对照人群。另外，在T1 0/0型和T1 0/0-M1 0/0型的构成比上存在着最大级别越低构成比越高的显著趋势。结果提示，GSTs基因型检测与膀胱脱落细胞检查可能是两种具有不同意义的指标，前者反映的是易感性，后者则可认为是临床前期诊断指标，两者之间不存在相关关系是可能的。但本研究中出现的负相关关系是否反映GST M1和T1 0/0基因型对膀胱上皮细胞异变的逆转具有一定的保护作用，值得进一步研究。
연구지재탐토여방광암발생위험유관적곡광감태S-전이매(GSTs)M1화T1기인형적다태성적분포여유련분알접촉적방광암고위인군의학감호결과적관계。장상해시염료화공행업적련분알접촉인군안감호적파씨분급결과분조，분별여건강대조인군작각충기인형구성비적비교，병진행각조간적구성비추세분석。결과발현，접촉인군내감호사중최대급별≤2급조적T1 0/0형、M1 0/0형、화T1 0/0-M1 0/0형화2.5급조적M1 0/0형、T1 0/0-M1 0/0형적구성비균현저고우대조인군；평균급별재1.7급이하자중T1 0/0형화T1 0/0-M1 0/0형구성비균현저고우대조인군。령외，재T1 0/0형화T1 0/0-M1 0/0형적구성비상존재착최대급별월저구성비월고적현저추세。결과제시，GSTs기인형검측여방광탈락세포검사가능시량충구유불동의의적지표，전자반영적시역감성，후자칙가인위시림상전기진단지표，량자지간불존재상관관계시가능적。단본연구중출현적부상관관계시부반영GST M1화T1 0/0기인형대방광상피세포이변적역전구유일정적보호작용，치득진일보연구。
This study was aimed to ascertain the relationship between the distribution of glutathione S-transferase(GSTs)M1 and T1 gene polymorphism related to the ris k of bladder cancer development and the medical surveillance for the bladder cancer high risk population exposed to benzidine.The population occupationally exposed to benzidine in Shanghai dyestuff industry was divided into several groups based on the surveillance results with Papanicoloaus method,and the proportions of genotypes in each group were compared with that in the control population.The trend analyses was made for the inter-group proportions.The results showed that the proportions of T1 0/0,M1 0/0,and T1 0/0-M1 0/0 in the group of ≤2,and M1 0/0 and T1 0/0-M1 0/0 in the group of 2.5 of the highest grade during the surveillance were higher than those in the control population.The proportions of T1 0/0and T1 0/0-M1 0/0 in the group of 1.7 of the average grade du ring the surveillance were higher than that in the control population.Moreover,th ere was a significant trend of the lower highest grade with the higher proportion in T1 0/0 and T1 0/0-M1 0/0.The results suggested that the detection for GSTs genotype may be the index different to the urine exfoliation examination.The former reflected the susceptibility,and the latter should be regarded as the diagnostic index for pre-clinic.Maybe,there is no correlation between them.However,whether the fact of the negative correlation presented in this study reflects GSTs M1 and T1 genotype 0/0 may protect the reversion from the variation of bladder epithelia,will be valuable for further research.